Cabrejos Azama, JatsuéHamdan Alkhraisat, MohammadRueda Rodríguez, María Del CarmenTorres García Denche, JesúsBlanco Jerez, LuisLópez Cabarcos, Enrique2023-06-192023-06-192014Cabrejos-Azama J, Alkhraisat MH, Rueda C, Torres J, Blanco L, López-Cabarcos E. Magnesium substitution in brushite cements for enhanced bone tissue regeneration. Materials Science and Engineering: C 2014;43:403–10. https://doi.org/10.1016/j.msec.2014.06.036.0928-493110.1016/j.msec.2014.06.036https://hdl.handle.net/20.500.14352/34056We have synthesized calcium phosphate cements doped with different amounts of magnesium (Mg-CPC)with a twofold purpose: i)to evaluate in vitro the osteoblast cell response to this material and ii) to compare the bone regeneration capacity of the doped material with a calcium cement prepared without magnesium (CPC). Cell proliferation and in vivo response increased in the Mg-CPC's in comparison with CPC. The Mg-CPC's have promoted higher new bone formation than the CPC (p<0.05). The cytocompatibility and histomorfometric analysis performed in the rabbit calvaria showed that the incorporation of magnesium ions in CPC improves osteoblasts proliferation and provides higher new bone formation. The development of a bone substitute with controllable biodegradable properties and improved bone regeneration can be considered a step toward personalized therapy that can adapt to patient needs and clinical situations.engjournal articlehttps//doi.org/10.1016/j.msec.2014.06.036http://www.elsevier.com/locate/msecopen access615.46Calcium phosphate cementBrushiteMagnesiumOsteoblastBone regenerationMateriales dentales3213.13 Ortodoncia-Estomatología