Rodriguez, JeanGiorgi Poletti, GiorgioRuiz Serrano, MiriamLópez-Alvarado Gutiérrez, María PilarMenéndez Ramos, José Carlos2025-12-102025-12-102011Giorgi G, Miranda S, Ruiz M, et al. A General, Diastereoselective Synthesis of Highly Functionalized Bicyclo[ n .3.1]alkane Systems Based on an Anionic Domino Reaction of α‐Nitrocycloalkanones. Eur J Org Chem 2011;2011:2101–10. https://doi.org/10.1002/ejoc.201001672.1434-193X10.1002/ejoc.201001672https://hdl.handle.net/20.500.14352/128700The base-promoted Michael–aldol anionic domino reactions of cyclic α-nitro ketones and α,β-unsaturated aldehydes afforded bicyclo[n.3.1]alkanone systems of seven different ring sizes (n = 3–9), normally in excellent yields. This can be considered the first general method for the synthesis of this type of carbocycle. Furthermore, up to four stereocentres are generated, three of which are contiguous and include a functionalized quaternary bridgehead carbon atom. The diastereoselectivity was often complete, was much higher than in les general reactions based on related domino processes, and involved the generation of a different major diastereomer due to the control of the Michael and aldol individual steps of the reaction by the nitro groupengjournal article1099-0690https://doi.org/10.1002/ejoc.201001672restricted access547Bicyclic compoundsDomino reactionsMichael additionAldol reactionsDiastereoselectivityQuímica orgánica (Química)2306.04 Química de Los Compuestos Bicíclicos