Clerigué Louzado, JoséRamos García, María TeresaMenéndez Ramos, José Carlos2023-06-172023-06-172021-03-021420-304910.3390/molecules26051330https://hdl.handle.net/20.500.14352/7095The aza-vinylogous Povarov reaction between aromatic amines, α-ketoaldehydes or α-formylesters and α,β-unsaturated dimethylhydrazones was carried out in a sequential three-component fashion under mechanochemical conditions. Following extensive optimization work, the reaction was performed on a vibratory ball mill operating at 20 Hz and using zirconium oxide balls and milling jar, and afforded 1,2,3,4-tetrahydroquinolines and 1,2,3,4-tetrahydro- 1,5-naphthyridines functionalized at C-2, C-4 and also at C-6, in the latter case. This protocol generally afforded the target compounds in good to excellent yields and diastereoselectivities. A comparison of representative examples with the results obtained under conventional conditions revealed that the mechanochemical protocol affords faster Povarov reactions in comparable yields using a solvent-less environment.engAtribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/journal articlehttps://www.mdpi.com/journal/moleculesopen access547Nitrogen heterocyclesVibratory ball millingTetrahydroquinolinesTetrahydro-15-naphthyridinesQuímica orgánica (Farmacia)