Romero Martínez, Manuel AlejandroEgea, JavierGonzález-Muñoz, GemaMartín De Saavedra Álvarez De Uribarri, María DoloresBarrio, Laura delRodríguez-Franco, María IsabelConde, SantiagoLópez, ManuelaVillarroya, MercedesRíos, Cristóbal de los2024-01-312024-01-3120141948-719310.1021/cn500131thttps://hdl.handle.net/20.500.14352/96908The neuroprotective profile of the dibenzothiadiazepine ITH12410/SC058 (2-chloro-5,6-dihydro-5,6-diacetyldibenzo[b,f][1,4,5]thiadiazepine) against several neurotoxicity models related to neurodegenerative diseases is herein described. ITH12410/SC058 protected SH-SY5Y cells against the loss of cell viability elicited by amyloid beta peptide and okadaic acid, a selective inhibitor of phosphoprotein phosphatase 2A that induces neurofibrillary tangle formation. Furthermore, ITH12410/SC058 is neuroprotective against several in vitro models of oxidative stress, that is, H2O2 exposure or incubation with rotenone plus oligomycin A in SH-SY5Y cells, and oxygen and glucose deprivation followed by reoxygenation in rat hippocampal slices. By contrast, ITH12410/SC058 was unable to significantly protect SH-SY5Y neuroblastoma cells against the toxicity elicited by Ca2+ overload. Our results confirm the hypothesis that the dibenzothiadiazepine ITH12410/SC058 features its neuroprotective actions in a multitarget fashion, and is a promising drug for the treatment of neurodegenerative diseasesengjournal articlehttps://doi.org/10.1021/cn500131thttps://pubs.acs.org/doi/10.1021/cn500131trestricted accessDibenzothiadiazepineNeurodegenerative diseasesOxidative stressAlzheimer’s diseaseAmyloid betaNeurofibrillary tanglesNeuroprotective drugsCiencias Biomédicas24 Ciencias de la Vida