Petcu, SoniaLázaro Milla, CarlosRodríguez, JavierIriepa, IsabelBautista-Aguilera, ÓscarAragoncillo Abanades, CristinaAlonso Gómez, José MiguelAlmendros Requena, Pedro2024-01-092024-01-092023Petcu A S, Lázaro-Milla C, Rodríguez F J, Iriepa I, Bautista-Aguilera, Ó M, Aragoncillo C, Alonso J M, Almendros P. Straightforward Synthesis of Bis[(trifluoromethyl)sulfonyl]ethylated Isocoumarins from 2-Ethynylbenzoates. J. Org. Chem. 2023 , 88, 7373-7380.0022-326310.1021/acs.joc.3c00611https://hdl.handle.net/20.500.14352/91922Herein, we report a facile isocoumarin and isoquinolone preparation by taking advantage of an initial bis(triflyl)ethylation [triflyl = (trifluoromethyl)sulfonyl] reaction, followed by heterocyclization, which contrasts with our previous results on cyclobutene formation. The efficiency of the catalyst- and irradiation-free heterocyclization/bis(triflyl)ethylation sequence showed exquisite dependence on the electronic nature of the substituents at the 2-ethynylbenzoate(benzamide) precursors. Molecular docking of model bis(triflyl)ethylated isocoumarins on human acetylcholinesterase (hAChE) revealed promising biological activities through selective coordination on both the catalytic active site and peripheral active site.engjournal article1520-6904https://doi.org/10.1021/acs.joc.3c00611open access547IsocoumarinIsoquinoloneTriflyl groupQuímica orgánica (Química)23 Química