Rancán, LisaHuerta Martínez, Luis JavierCusati, GErquicia, IIsea, JParedes Royano, Sergio DamiánGarcía, CGarutti Martínez, IgnacioSimón Adiego, Carlos MaríaVara Ameigeiras, Elena María2024-02-082024-02-082014-12-15Rancan L, Huerta L, Cusati G, Erquicia I, Isea J, Paredes SD, García C, Garutti I, Simón C, Vara E. Sevoflurane prevents liver inflammatory response induced by lung ischemia-reperfusion. Transplantation. 2014 Dec 15;98(11):1151-7. doi: 10.1097/TP.0000000000000408. PMID: 25269024.10.1097/TP.0000000000000408https://hdl.handle.net/20.500.14352/100164Background: Transplants cause ischemia-reperfusion (IR) injury that can affect distant organs. Liver is particularly sensitive to IR injury. The present randomized experimental study was designed to investigate a possible protective effect of sevoflurane against liver inflammatory response to lung IR in a lung upper lobe left autotransplant model. Methods: Two groups (sevoflurane and control) of eight swines each were submitted to upper lobe left lung autotransplant. Hypnotic maintenance was performed with sevoflurane 3% or propofol 8 to 10 mg/kg per hr until pneumonectomy was done; then propofol was used for all animals. Blood and liver samples were taken in four different moments: prepneumonectomy, prereperfusion, 10 min postreperfusion and 30 min postreperfusion to measure levels of interleukin (IL)-1β, IL-10, tumor necrosis factor (TNF)-α, monocyte chemotactic protein (MCP)-1, nuclear factor (NF)-κB, C-reactive protein, ferritin and caspase 3. Non-parametric test was used to find statistical meaning. Results: Lung IR markedly increased the expression of TNF-α, IL-1β, MCP-1, NF-κB and caspase activity in control livers compared with basal levels, whereas liver IL-10 expression decreased 10 and 30 min post-reperfusion. Sevoflurane significantly decreased TNF-α, IL-1β, MCP-1, NF-κB liver expression and caspase 3 activity. Sevoflurane also reverted the lung IR-induced decrease in IL-10 expression. Conclusions: The present results indicate that lung IR caused hepatic injury. Sevoflurane attenuated liver injury in a model of upper lobe left lung autotransplant in pigs.engjournal articlehttps://journals.lww.com/transplantjournal/fulltext/2014/12150/sevoflurane_prevents_liver_inflammatory_response.8.aspxhttps://pubmed.ncbi.nlm.nih.gov/25269024/restricted access617-089.5Ciencias Biomédicas32 Ciencias Médicas