Alkhalidi, Bashar A.Alkhatib, Hatim S.Saleh, MohammadHamed, SajaBustanji, YasserAl Bujuq, NaderNajib, NajiTorrado Durán, SusanaSallam, Al-Sayed2024-02-052024-02-052018-12-071083-745010.1080/10837450.2018.1547749https://hdl.handle.net/20.500.14352/98820Objective: To prepare and characterize the physicochemical and pharmacokinetic properties of clarithromycin laurate (CLM-L), a fatty acid salt of clarithromycin (CLM). Methods: CLM-L was prepared by a simple co-melting process. The formation of CLM-L was confirmed using FTIR, 1H NMR, and 13C NMR. Solubility, intrinsic dissolution rate (IDR), and partitioning properties of CLM-L were determined and compared to those of CLM. Bioavailability of CLM from CLM-L tablets was evaluated in healthy volunteers and compared to immediate release CLM tablets. Results: CLM-L showed lower aqueous solubility, higher partitioning coefficient, and slower dissolution rate. Tablets of CLM-L also showed a significantly slower in vitro release in comparison to CLM tablets. Cmax, Tmax and AUC of CLM-L tablets and immediate release CLM tablets did not show a significant difference. However, the AUC0!1 for the CLM-L tablets tended to be higher than that of CLM tablets at all-time points. Conclusion: CLM-L was successfully prepared and its formation was confirmed. CLM-L was more hydrophobic than CLM. It exhibited a slight in vivo absorption enhancement in comparison to CLM. However, its pharmacokinetic behavior was comparable to that of CLM.engjournal article1097-9867https://doi.org/10.1080/10837450.2018.1547749https://www.tandfonline.com/doi/full/10.1080/10837450.2018.1547749restricted access615.01/.03Clarithromycin lauratePicochemical characterizationBioavailabilityFatty acid saltCiencias BiomédicasFarmacología (Farmacia)32 Ciencias Médicas