Cruz, GuillermoAcosta, JavierDel Arco, JonClemente Suarez, Vicente JavierDeroncele, VíctorFernández Lucas, Jesús2024-10-102024-10-102022Cruz, Guillermo, et al. «Enzyme‐mediated Synthesis of Molnupiravir: Paving the Way for the Application of Biocatalysis in Pharmaceutical Industry». ChemCatChem, vol. 14, n.o 13, julio de 2022, p. e202200140. DOI.org (Crossref), https://doi.org/10.1002/cctc.202200140.1867-388010.1002/cctc.202200140https://hdl.handle.net/20.500.14352/108868Molnupiravir (Lagevrio®) is an orally-administered anti-COVID-19 agent. Due to the urgency to meet the worldwide demand and the growing environmental concern, there is a need for speed in the industrial implementation of novel and efficient bioprocesses for Molnupiravir synthesis. This concept paper aims to review the most relevant milestones that have guided important developments in the enzyme-mediated synthesis of Molnupiravir, including detailed comments on the advantages and drawbacks of the different synthetic routes. Finally, based on a personal perspective, new greener processes for Molnupiravir manufacturing are proposed and discussed.engAttribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/journal article1867-3899https://doi.org/10.1002/cctc.202200140https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/cctc.202200140open access577.15578.160615.281.8661.12Molnupiravir(Chemo)enzymatic processesEcofriendlyIndustrial scale-uBioquímica (Biología)Biología molecular (Biología)BiotecnologíaMedicamentosQuímica farmaceútica2403 Bioquímica2415 Biología Molecular2420 Virología2390 Química Farmacéutica2302.09 Enzimología3209.08 Preparación de Medicamentos