Cañadas Suárez, María Del PilarGarcía González, MontserratCañones Zafra, RafaelTeus Guezala, Miguel Ángel2023-06-222023-06-222022-01-292075-441810.3390/diagnostics12020343https://hdl.handle.net/20.500.14352/72392Neuro Lyme disease is caused by several bacteriae of the Borreliaceae family, such as Borrelia Miyamotoi. In late stages of illness, patients with Lyme disease may develop chronic neurologic symptoms such as cognitive disturbances or small fiber peripheral neuropathy. Confocal microscopy is a non-invasive method designed to evaluate the human cornea in vivo. Thus, all the corneal layers, including the cells and the sub-basal nerve plexus, can be easily visualized and analyzed. This is the first report of the morphology of small-fiber peripheral neuropathy analyzed by confocal microscopy in a patient diagnosed of neuro Lyme disease. The decrease in the number of unmyelinated sub-basal nerve fibers with abundant presence of dendritic cells (DC) in comparison with healthy corneas strongly supports the diagnosis of small fiber peripheral neuropathy in a case of neuroborreliosis disease.engAtribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/journal articlehttps://doi.org/10.3390/diagnostics12020343https://www.mdpi.com/2075-4418/12/2/343open access616.9617.713-073.75corneal confocal microscopyLyme diseasesmall fiber neuropathysub-basal nerve plexusNeurociencias (Medicina)OftalmologíaTécnicas de la imagen2490 Neurociencias3201.09 Oftalmología