Alberca, SaúlRomero Parra, JavierFernández López, IsraelFernández, RosarioLassaletta, José M.Monge, David2024-10-162024-10-16202410.1039/d4sc00822ghttps://hdl.handle.net/20.500.14352/108997Catalysts generated in situ by the combination of pyridine–hydrazone N,N-ligands and Pd(TFA)2 have been applied to the addition of arylboronic acids to formylphosphonate-derived hydrazones, yielding α-aryl α-hydrazino phosphonates in excellent enantioselectivities (96 → 99% ee). Subsequent removal of the benzyloxycarbonyl (Cbz) N-protecting group afforded key building blocks en route to appealing artificial peptides, herbicides and antitumoral derivatives. Experimental and computational data support a stereochemical model based on aryl-palladium intermediates in which the phosphono hydrazone coordinates in its Z-configuration, maximizing the interactions between the substrate and the pyridine–hydrazone ligand.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/journal articleDOI https://doi.org/10.1039/D4SC00822Ghttps://pubs.rsc.org/en/content/articlelanding/2024/sc/d4sc00822gopen access547Química orgánica (Química)2306 Química Orgánica