Hernandez-Rocamora, VictorMaestro García-Donas, María Beatrizde Waal, BasMorales, MaríaGarcia, PedroMeijer, BertMerx, MaartenSanz, Jesús2024-01-232024-01-162024-01-232009Hernández‐Rocamora, Víctor M., et al. «Multivalent Choline Dendrimers as Potent Inhibitors of Pneumococcal Cell‐Wall Hydrolysis». Angewandte Chemie International Edition, vol. 48, n.o 5, enero de 2009, pp. 948-51. https://doi.org/10.1002/anie.200803664.1433-785110.1002/anie.200803664https://hdl.handle.net/20.500.14352/93420.2Dendritic cell-wall mimics: Choline-binding proteins from Streptococcus pneumoniae recognize distinctive multivalent choline architectures on the bacterial cell wall. Choline-functionalized dendrimers are potent inhibitors of these essential enzymes, with a 103–104-fold higher affinity than free choline, resulting in inhibition of autolysis and cell separation in bacterial cultures at low micromolar concentrationsengAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/journal article1521-3773https://doi.org/10.1002/anie.200803664open access577.1Bioquímica (Química)2403 Bioquímica