Benede Ubieto, RaquelEstévez Vázquez, OlgaCubero Palero, Francisco JavierNevzorova, Yulia2023-06-162023-06-162020-02-181178-700710.2147/DMSO.S234665https://hdl.handle.net/20.500.14352/6234The epidemic of the century, Diabetes Mellitus (DM) is continuously rising. Intensive research is urgently needed whereby experimental models represent an essential tool to optimise the diagnostic strategy and to improve therapy. In this review, we describe the central principles of the metabolic tests available in order to study glucose and insulin homeostasis in mice, focusing on the most widely used – the glucose and insulin tolerance tests. We provide detailed experimental procedures as well as the practical implementation of these methods and discuss the main factors that should be taken into account when using this methodology.engAtribución-NoComercial 3.0 Españahttps://creativecommons.org/licenses/by-nc/3.0/es/journal article1178-7007https//doi.org/10.2147/DMSO.S234665https://www.dovepress.com/guidelines-and-considerations-for-metabolic-tolerance-tests-in-mice-peer-reviewed-article-DMSOopen access577.1616.4Metabolic tolerance testT2DMObesityMetabolic syndromeInsulin resistanceGlucose intoleranceEndocrinologíaBioquímica (Biología)InmunologíaGastroenterología y hepatología3205.02 Endocrinología2302 Bioquímica24 Ciencias de la Vida2412 Inmunología3206 Ciencias de la Nutrición