A novel short-term plasticity of intrinsic excitability in the hippocampal CA1 pyramidal cells

Sánchez-Aguilera López, AlbertoSánchez Alonso, José LuisVicente Torres, María ÁngelesColino Matilla, María Asunción2024-01-232024-01-232014-07Sánchez-Aguilera López, A., Sánchez Alonso, J. L., Vicente Torres, M. Á. & Colino Matilla, M. A. «A Novel Short‐term Plasticity of Intrinsic Excitability in the Hippocampal CA1 Pyramidal Cells». The Journal of Physiology, vol. 592, n.o 13, julio de 2014, pp. 2845-64. DOI.org (Crossref), https://doi.org/10.1113/jphysiol.2014.273185.0022-375110.1113/jphysiol.2014.273185https://hdl.handle.net/20.500.14352/94837Changes in neuronal activity often trigger compensatory mechanisms aimed at regulating network activity homeostatically. Here we have identified and characterized a novel form of compensatory short-term plasticity of membrane excitability, which develops early after the eye-opening period in rats (P16–19 days) but not before that developmental stage (P9–12 days old). Holding the membrane potential of CA1 neurons right below the firing threshold from 15 s to several minutes induced a potentiation of the repolarizing phase of the action potentials that contributed to a decrease in the firing rate of CA1 pyramidal neurons in vitro. Furthermore, the mechanism for inducing this plasticity required the action of intracellular Ca2+ entering through T-type Ca2+ channels. This increase in Ca2+ subsequently activated the Ca2+ sensor K+ channel interacting protein 3, which led to the increase of an A-type K+ current. These results suggest that Ca2+ modulation of somatic A-current represents a new form of homeostatic regulation that provides CA1 pyramidal neurons with the ability to preserve their firing abilities in response to membrane potential variations on a scale from tens of seconds to several minutes.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/A novel short-term plasticity of intrinsic excitability in the hippocampal CA1 pyramidal cellsjournal article1469-7793https//doi.org/10.1113/jphysiol.2014.27318524756640https://physoc.onlinelibrary.wiley.com/doi/10.1113/jphysiol.2014.273185open access611.81Neurociencias (Medicina)2490 Neurociencias