Sánchez Tena, Miguel ÁngelCleva, Jose MiguelVilla Collar, CésarÁlvarez, MartaRuiz Pomeda, AliciaMartínez Pérez, ClaraAndreu Vázquez, CristinaChamorro, EvaÁlvarez Peregrina, CristinaHee-Young Choi2024-05-172024-05-172024-02-01Sánchez-Tena MÁ, Cleva JM, Villa-Collar C, Álvarez M, Ruiz-Pomeda A, Martinez-Perez C, Andreu-Vazquez C, Chamorro E, Alvarez-Peregrina C. Effectiveness of a Spectacle Lens with a Specific Asymmetric Myopic Peripheral Defocus: 12-Month Results in a Spanish Population. Children (Basel). 2024 Feb 1;11(2):177. doi: 10.3390/children11020177. PMID: 38397289; PMCID: PMC10887607.10.3390/children11020177https://hdl.handle.net/20.500.14352/104200This article belongs to the Section Global and Public Health. Received: 30 November 2023; Revised: 10 January 2024; Accepted: 26 January 2024; Published: 1 February 2024Background: Different designs of ophthalmic lenses have been studied to control the progression of myopia in children. This study aims to evaluate the short-term efficacy of a new design of ophthalmic lens with asymmetric myopic peripheral defocus (MPDL) on myopia progression in children compared to a control group wearing a single-vision lens (SVL). Methods: Children aged 5 to 12 with myopia up to -0.50 D, astigmatism and anisometropia under 1.50 D, and corrected visual acuity over 20/20 were randomized to either the study group (MPDL) or control group (SVL). The myopia progression was evaluated by measuring axial length (AL) growth (IOL Master; Zeiss) over a period of one year. Results: Ninety-two subjects were recruited. Forty-six children were randomly assigned to the control group, and 46 to the study group. In total, 83 children completed the clinical trial, with a mean age of 10.81 [9.53-11.92] years, among which 59.04% were female. After one year of treatment, there was less AL elongation in the study group compared to the control group (0.16 ± 0.16 mm vs. 0.24 ± 0.16 mm, p = 0.034). Conclusions: The MPDL significantly reduced the absolute growth of AL by 39% (p = 0.014) and relative growth of AL by 37.3% (p = 0.012) after 12 months in comparison to the control group in a Spanish population.engAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/journal article2227-9067https://doi.org/10.3390/children1102017738397289https://www.mdpi.com/2227-9067/11/2/177#open access617.7-089.243617.753.2681.735childrenefficacymyopiamyopic peripheral defocus lensesÓptica y optometríaÓptica oftálmicaPediatría2209.15 Optometría3311.09 Lentes2209.24 Física de la Visión