Moraga Yébenes, AnaGómez Vallejo, VanessaCuartero Desviat, María IsabelSzczupak, BoguslawSan Sebastián, EnekoMarkuerkiaga, IratiPradillo Justo, Jesús MiguelHiguchi, MakotoLlop, JordiMoro Sánchez, María ÁngelesMartín, AbrahamLizasoaín Hernández, Ignacio2024-01-292024-01-292016-01-19Moraga A, Gómez-Vallejo V, Cuartero MI, Szczupak B, San Sebastián E, Markuerkiaga I, Pradillo JM, Higuchi M, Llop J, Moro MÁ, Martín A, Lizasoain I. Imaging the role of toll-like receptor 4 on cell proliferation and inflammation after cerebral ischemia by positron emission tomography. J Cereb Blood Flow Metab. 2016 Apr;36(4):702-8. doi: 10.1177/0271678X156276570271-678X1559-701610.1177/0271678x15627657https://hdl.handle.net/20.500.14352/95797The influence of toll-like receptor 4 on neurogenesis and inflammation has been scarcely explored so far by using neuroimaging techniques. For this purpose, we performed magnetic resonance imaging and positron emission tomography with 3'-deoxy-3'-[(18)F]fluorothymidine and [(11)C]PK11195 at 2, 7, and 14 days following cerebral ischemia in TLR4(+/+)and TLR4(-/-)mice. MRI showed similar infarction volumes in both groups. Despite this, positron emission tomography with 3'-deoxy-3'-[(18)F]fluorothymidine and [(11)C]PK11195 evidenced an increase of neurogenesis and a decrease of inflammation in TLR4(-/-)mice after ischemia. These results evidence the versatility of neuroimaging techniques to monitor the role of toll-like receptor 4 after cerebral ischemia.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/journal articlehttps://journals.sagepub.com/home/jcbPMC4821030open access615.01/.033′-deoxy-3′-[18F]fluorothymidinePositron emission tomographyT2W-MRI[11C]PK11195Cerebral ischemiaMagnetic resonance imagingMiddle cerebral artery occlusionToll-like receptor 4Ciencias Biomédicas32 Ciencias Médicas