Vallet Regí, María Dulce NombreColilla Nieto, MontserratIzquierdo Barba, IsabelManzano García, Miguel2023-06-172023-06-172017-12-251420-304910.3390/molecules23010047https://hdl.handle.net/20.500.14352/18309RESEARCHER ID M-3378-2014 (María Vallet Regí) ORCID 0000-0002-6104-4889 (María Vallet Regí) RESEARCHER ID N-4628-2014 (Montse Colilla Nieto) RESEARCHER ID M-9921-2014 (Isabel Izquierdo Barba) ORCID 0000-0002-4139-4646 (Isabel Izquierdo Barba) ORCID 0000-0003-1961-4160 (Montse Colilla Nieto) RESEARCHER ID K-3719-2014 (Miguel Manzano García) ORCID 0000-0001-6238-6111 (Miguel Manzano García)This manuscript reviews the recent progress on mesoporous silica nanoparticles as drug delivery systems. Their intrinsic structural, textural and chemical features permit to design versatile multifunctional nanosystems with the capability to target the diseased tissue and release the cargo on demand upon exposition to internal or external stimuli. The degradation rate of these nanocarriers in diverse physiological fluids is overviewed obeying their significance for their potential translation towards clinical applications. To conclude, the balance between the benefits and downsides of this revolutionary nanotechnological tool is also discussed.engAtribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/journal articlehttps://doi.org/10.3390/molecules23010047http://www.ucm.es/valletregigrouphttps://www.mdpi.com/1420-3049/23/1/47open access546615.46mesoporous silica nanoparticlesmultifunctional nanosystemselective targetingstimuliresponsive drug deliveryin vitro degradationbenefits and downsidesclinical translationbiosafetyMaterialesQuímica inorgánica (Química)3312 Tecnología de Materiales2303 Química Inorgánica