Salazar Roa, MaríaCarracedo, ArkaitzSalanueva, ÍñigoHernández Tiedra, SoniaEgia, AinaraLorente Pérez, María Del MarVázquez, PatriciaTorres, SofiaIovanna, JuanGuzmán Pastor, ManuelBoya, PatriciaVelasco Díez, Guillermo2024-02-012024-02-012009Salazar, M., Carracedo, A., Salanueva, Í. J., Hernández-Tiedra, S., Egia, A., Lorente, M., … Velasco, G. (2009). TRB3 links ER stress to autophagy in cannabinoid antitumoral action. Autophagy, 5(7), 1048–1049. https://doi.org/10.4161/auto.5.7.95081554-862710.4161/auto.5.7.9508https://hdl.handle.net/20.500.14352/97786Δ9-tetrahydrocannabinol (THC), the main active component of marijuana, is being investigated as a potential anti-tumoral agent. We find that THC stimulates an endoplasmic reticulum (ER) stress-related signaling pathway, which activates autophagy via inhibition of the Akt/mTORC1 axis. We also show that autophagy is upstream of apoptosis in cannabinoid-induced cancer cell death and that activation of this pathway is necessary for the anti-tumoral action of cannabinoids in vivo.engjournal article1554-8635https://doi.org/10.4161/auto.5.7.9508restricted accessAutophagyCannabinoidsTRB3mTORBiología celular (Biología)2403 Bioquímica