Xu, XiaoqingYu, YixinLing, MinAres Lombán, IrmaMartínez Caballero, MartaLópez Torres, BernardoMaximiliano Guerra, Jorge EnriqueMartínez Larrañaga, María RosaWang, XuAnadón Navarro, Arturo RamónMartínez Caballero, María Aranzazu2024-04-052024-04-052023-10-03Xu, X., Yu, Y., Ling, M., Ares, I., Martínez, M., Lopez-Torres, B., ... & Martínez, M. A. (2023). Oxidative stress and mitochondrial damage in lambda-cyhalothrin toxicity: A comprehensive review of antioxidant mechanisms. Environmental Pollution, 122694.0269-749110.1016/j.envpol.2023.122694https://hdl.handle.net/20.500.14352/102753Credit author statement: Xiaoqing Xu, Yixin Yu, Min Ling, Irma Ares, Marta Martínez, Bernardo Lopez-Torres, Jorge-Enrique Maximiliano, María-Rosa MartínezLarranaga: ˜ Conceptualization, Methodology, Investigation, Data curation, Writing - original draft, Visualization. Xu Wang, Arturo Anadon and María-Aranzazu ´ Martínez: Conceptualization, Supervision, Writing – original draft, Writing – review & editing, Project administration. All authors have approved the final version of this manuscript.Lambda-cyhalothrin, also known as cyhalothrin, is an efficient, broad-spectrum, quick-acting pyrethroid insecticide and acaricide and the most powerful pyrethroid insecticide in the world. However, there is increasing evidence that lambda-cyhalothrin is closely related to a variety of toxicity drawbacks (hepatotoxicity, nephrotoxicity, neurotoxicity and reproductive toxicity, among others) in non-target organisms, and oxidative stress seems to be the main mechanism of toxicity. This manuscript reviews the oxidative and mitochondrial damage induced by lambda-cyhalothrin and the signalling pathways involved in this process, indicating that oxidative stress occupies an important position in lambda-cyhalothrin toxicity. The mechanism of antioxidants to alleviate the toxicity of lambda-cyhalothrin is also discussed. In addition, the metabolites of lambda-cyhalothrin and the major metabolic enzymes involved in metabolic reactions are summarized. This review article reveals a key mechanism of lambda-cyhalothrin toxicity-oxidative damage and suggests that the use of antioxidants seems to be an effective method for preventing toxicity.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/journal article1873-6424open access636.09:615ToxicityLambda-cyhalothrinMetabolismOxidative stressMitochondrial damageCiencias Biomédicas3214 Toxicología