Cicuéndez Maroto, MónicaPortolés Pérez, María TeresaIzquierdo Barba, IsabelVallet Regí, María Dulce Nombre2024-01-302024-01-302012Cicuéndez, Mónica, et al. «New Nanocomposite System with Nanocrystalline Apatite Embedded into Mesoporous Bioactive Glass». Chemistry of Materials, vol. 24, n.o 6, marzo de 2012, pp. 1100-06. https://doi.org/10.1021/cm203416x.0897-475610.1021/cm203416xhttps://hdl.handle.net/20.500.14352/96645Crystalline nanoparticles are very attractive building blocks for the preparation of nanostructured materials. These particles can be dispersed in different noncrystalline mesostructured matrixes in order to obtain nano-composite systems which combine the properties of both components broadening their functionality. In the present study, a novel nanocomposite bioceramic formed by nanocrystalline apatite particles uniformly embedded into a mesostructured SiO2−CaO−P2O5 glass wall has been synthesized through the evaporation-induced self-assembly (EISA) method, commonly used for mesoporous bioactive glass synthesis, but accelerating the sol−gel apatite crystallization rate by strong acidification. Moreover, the use of F127 surfactant as a structure directing agent in this synthesis has allowed the homogeneous nanocrystalline apatite particles incorporation inside of the amorphous mesoporous glass. In vitro bioactive assays have shown a fast apatite-like phase formation similar to that exhibited by mesoporous bioactive glasses. Furthermore, the response of L929 fibroblasts and Saos-2 osteoblasts to this new nanocomposite has indicated a significant improvement in its biocompatibility compared with conventional mesoporous bioactive glasses.engjournal article1520-5002https://doi.org/10.1021/cm203416xrestricted access539.2:62-181.4Nanocomposite systemNanocrystalline apatite particlesMesoporous bioactive glassesBiocompatibilityCell responseCiencias Biomédicas23 Química