Castillo, Rafael R.Vallet Regí, María Dulce Nombre2023-06-172023-06-172019-02-201422-006710.3390/ijms20040929https://hdl.handle.net/20.500.14352/13122RESEARCH ID L-2854-2014  (Rafael Castillo Romero) ORCID 0000-0003-1957-3098 (Rafael Castillo Romero) RESEARCHER ID M-3378-2014 (María Vallet Regí) ORCID 0000-0002-6104-4889 (María Vallet Regí)The rise and development of nanotechnology has permitted to create of a wide number of systems able to accomplish new and advantageous features to treat cancer. However in many cases, the lone application of those new nanotherapeutics has proven not to be enough to achieve acceptable therapeutic efficacies. Hence, to avoid these limitations, the scientific community has been embarked on the development of single formulations capable of combining functionalities. Among all possible components, silica –either solid or mesoporous–, has become of importance as connecting and coating material for those new-generation therapeutic nanodevices. In the present review there are visited the most recent examples of fully-inorganic silica-based functional composites, paying especial attention to those with potential biomedical applicability. Additionally, there will be given some highlights about their possible biosafety issues based on their chemical composition.engjournal articlehttps://doi.org/10.3390/ijms20040929http://www.ucm.es/valletregigrouphttps://www.mdpi.com/1422-0067/20/4/929open access615.46546Mesoporous SilicaMagneticPhotothermalPhotodynamicCombination therapyDrug DeliveryQuímica inorgánica (Farmacia)Tecnología farmaceútica