Castillo, Rafael R.Lozano Borregón, DanielVallet Regí, María Dulce Nombre2023-06-172023-06-172018-10-011043-180210.1021/acs.bioconjchem.8b00603https://hdl.handle.net/20.500.14352/12254RESEARCHER ID L-2854-2014 (Rafael Castillo Romero) ORCID 0000-0003-1957-3098 (Rafael Castillo Romero) RESEARCHER ID B-5081-2017 (Daniel Lozano Borregón) ORCID 0000-0001-5902-9201 (Daniel Lozano Borregón) RESEARCHER ID M-3378-2014 (María Vallet Regí) ORCID 0000-0002-6104-4889 (María Vallet Regí)ABSTRACT: Despite encapsulation of drugs claim to improve the therapeutic profile of free drugs, there are still important limitations in drug delivery. Focusing on cancer treatment, two promising implementations are combination therapy and targeted devices, aimed at increasing the drug effect either by achieving higher cell death rates or by discriminating between cell populations. However, for the time being, the scope of combining both approaches is unknown. To advance this knowledge, there has been designed a two-drug delivery system with dual cell-organelle targeting based on Mesoporous Silica Nanoparticles, known to be able to host drugs within their pores. In vitro results show a synergistic effect and high efficacy, demonstrating that the combination of dual therapy and targeting could still advance the development of drug delivery nanodevices against difficult-to-treat cancers.engjournal articlehttps://pubs.acs.org/action/showPublications?display=journalshttp://www.ucm.es/valletregigroupopen access615.46546MaterialesQuímica inorgánica (Química)3312 Tecnología de Materiales2303 Química Inorgánica