Concellón, José M.Suárez Álvarez, José RamónGarcía‐Granda, SantiagoDíaz, M. Rosario2024-02-022024-02-022004Concellón, J. M., Suárez, J. R., García‐Granda, S., & Díaz, M. R. (2004). Synthesis and Stereoselective Lithiation of Enantiopure 2‐(1‐Aminoalkyl) aziridine–Borane Complexes. Angewandte Chemie, 116(33), 4433-4436.1433-785110.1002/anie.200460120https://hdl.handle.net/20.500.14352/98456This work shows that the enantiopure 2-(1-aminoalkyl)aziridine–borane complexes can easily be obtained by two alternative methodologies: either reaction with BF3·Et2O followed by reduction with LiAlH4 or by direct reaction with a solution of BH3 in THF. In addition, regio- and stereoselective C3 deuteration or silylation of 2-(1- aminoalkyl)aziridine 1 can be effected by eprotonation/ deuteration or silylation/decomplexation of the corresponding borane complex 2. Application of this methodology to functionalize 2-(1-aminoalkyl)aziridines with other different electrophiles is currently under investigation.engjournal article1521-3773https://doi.org/10.1002/anie.200460120restricted access547BoranesSmall ring systemsLithiationEnantioselectivityDeuterationQuímica orgánica (Química)23 Química