Rodríguez-Avial Infante, IciarRamos, BelénRíos Dueñas, EstherCercenado Mansilla, EmiliaOrdobás, MaríaSanz Fernández, Juan Carlos2024-12-172024-12-172011-04-28Rodríguez-Avial IRamos B, Ríos E, Cercenado EOrdobás M, Sanz JC, 2011. Clonal Spread of Levofloxacin-Resistant Streptococcus pneumoniae Invasive Isolates in Madrid, Spain, 2007 to 2009. Antimicrob Agents Chemother 55:. https://doi.org/10.1128/aac.01380-100066-480410.1128/AAC.01380-10https://hdl.handle.net/20.500.14352/112751Among 1,349 Streptococcus pneumoniae invasive isolates, 45 (3.3%) were levofloxacin resistant. Serotype distribution was as follows: 8 (n = 32 isolates), 19A (n = 4 isolates), 7F (n = 3 isolates), 9V (n = 2 isolates), 10A (n = 1 isolate), 19F (n = 1 isolate), 6B (n = 1 isolate), and nontypeable (n = 1 isolate). Levofloxacin-resistant isolates had dual mutations in the gyrA and parC genes. Serotype 8 strains corresponded to a capsular switching of the Sweden15A-25 clone. Levofloxacin resistance was also detected among multiresistant (ST27619A, Spain9V-ST156, ST8819F, and ST15426B) and among usually antibiotic-susceptible (Netherlands7F-ST191, ST120119A, and ST263910A) clones.engjournal article1098-6596https://doi.org/10.1128/aac.01380-10https://journals.asm.org/doi/10.1128/aac.01380-10restricted access579.61Ciencias Biomédicas3201.03 Microbiología Clínica