Rodríguez García, AlbaMennesson, NicolasHernández Ibarburu, GemaMorales, María LuzGarderet, LaurentBouchereau, LorineAllain Maillet, SophiePiver, EricMarbán, IreneRubio, DavidBigot Corbel, EdithMartínez López, JoaquínLinares Gómez, MaríaHermouet, Sylvie2024-03-042024-03-042023-05-18Rodríguez García, A., Mennesson, N., Hernández Ibarburu, G. et al. «Impact of viral hepatitis therapy in multiple myeloma and other monoclonal gammopathies linked to hepatitis B or C viruses». Haematologica, mayo de 2023. DOI.org (Crossref), https://doi.org/10.3324/haematol.2023.283096.1592-87210390-607810.3324/haematol.2023.283096https://hdl.handle.net/20.500.14352/101902Subsets of multiple myeloma (MM) and monoclonal gammopathies of undetermined significance (MGUS) present with a monoclonal immunoglobulin specific for hepatitis C virus (HCV), thus are presumably HCV-driven, and antiviral treatment can lead to the disappearance of antigen stimulation and improved control of clonal plasma cells. Here we studied the role of hepatitis B virus (HBV) in the pathogenesis of MGUS and MM in 45 HBV-infected patients with monoclonal gammopathy. We analysed the specificity of recognition of the monoclonal immunoglobulin of these patients, and validated the efficacy of antiviral treatment (AVT). For 18/45 (40%) HBV-infected patients, the target of the monoclonal immunoglobulin was identified: the most frequent target was HBV (n=11), followed by other infectious pathogens (n=6), and glucosylsphingosine (n=1). Two patients whose monoclonal immunoglobulin targeted HBV (HBx and HBcAg), implying that their gammopathy was HBV-driven, received AVT and the gammopathy did not progress. AVT efficacy was then investigated in a large cohort of HBV-infected MM patients (n=1367), who received anti-HBV treatments, or not, and compared to a cohort of HCV-infected MM patients (n=1220). AVT significantly improved patient probability of overall survival (p=0.016 for the HBV-positive cohort, p=0.005 for the HCV-positive cohort). Altogether, MGUS and MM disease can be HBV- or HCV-driven in infected patients, and the study demonstrates the importance of antiviral treatment in such patients.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/journal articlehttps//doi.org/10.3324/haematol.2023.283096https://haematologica.org/indexopen access577.1577.2Ciencias BiomédicasBiología molecular (Farmacia)Bioquímica (Farmacia)24 Ciencias de la Vida