Person:
Maestro De Las Casas, María Del Carmen

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First Name
María Del Carmen
Last Name
Maestro De Las Casas
URI
https://hdl.handle.net/20.500.14352/81442
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Óptica y Optometría
Department
Optometría y Visión
Area
Anatomía y Embriología Humana
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2011 - 20162
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Author: Barrio Asensio, María Del Carmen ×

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    Occurrence of cleft-palate and alteration of Tgf-β3 expression and the mechanisms leading to palatal fusion in mice following dietary folic-acid deficiency
    (Cells Tissues Organs, 2011) Maldonado Bautista, Estela; Murillo González, Jorge Alfonso; Barrio Asensio, María Del Carmen; Río Sevilla, Aurora Del; Pérez De Miguelsanz, María Juliana; López Gordillo, Yamila; Partearroyo, Teresa; Paradas Lara, Irene; Maestro De Las Casas, María Del Carmen; Martínez Sanz, Elena; Varela Moreiras, Gregorio; Martínez Álvarez, María Concepción
    Folic acid (FA) is essential for numerous bodily functions. Its decrease during pregnancy has been associated with an increased risk of congenital malformations in the progeny. The relationship between FA deficiency and the appearance of cleft palate (CP) is controversial, and little information exists on a possible effect of FA on palate development. We investigated the effect of a 2–8 weeks’ induced FA deficiency in female mice on the development of CP in their progeny as well as the mechanisms leading to palatal fusion, i.e. cell proliferation, cell death, and palatal-shelf adhesion and fusion. We showed that an 8 weeks’ maternal FA deficiency caused complete CP in the fetuses although a 2 weeks’ maternal FA deficiency was enough to alter all the mechanisms analyzed. Since transforming growth factor beta 3 (TGF-β3) is crucial for palatal fusion and since most of the mechanisms impaired by FA deficiency were also observed in the palates of Tgf-β3 null mutant mice, we investigated the presence of TGF-beta 3 mRNA, its protein and phospho-SMAD2 in FA-deficient (FAD) mouse palates. Our results evidenced a large reduction in Tgf-β3 expression in palates of embryos of dams fed an FAD diet for 8 weeks; Tgf-β3 expression was less reduced in palates of embryos of dams fed an FAD diet for 2 weeks. Addition of Tgf-β3 to palatal-shelf cultures of embryos of dams fed an FAD diet for 2 weeks normalized all the altered mechanisms. Thus, an insufficient folate status may be a risk factor for the development of CP in mice, and exogenous Tgf-β3 compensates this deficit in vitro.
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    Project number: 144
    Elaboración de modelos anatómicos y embriológicos mediante la impresión 3D
    (2016) Arráez Aybar, Luis Alfonso; Barrio Asensio, María Del Carmen; Cabrera Parra, Walter; Cuadra Blanco, Crótida De La; Río Sevilla, Aurora Del; García Gómez, Susana; Herrera Lara, Manuel Eugenio; Maestro De Las Casas, María Del Carmen; Martínez Álvarez, María Concepción; Mérida Velasco, José Ramón; Murillo González, Jorge Alfonso; Naredo Sánchez, Esperanza; Quirós Terrón, Luis; Pérez De Miguelsanz, María Juliana
    La impresión 3D es un enfoque innovador en la docencia anatómica que puede proporcionar a los alumnos un material didáctico casi idéntico a la pieza embalsamada mitigando muchas de las múltiples controversias existentes en torno a la Disección