Person:
Martínez Álvarez, María Concepción

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First Name
María Concepción
Last Name
Martínez Álvarez
URI
https://hdl.handle.net/20.500.14352/81460
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Odontología
Department
Area
Anatomía y Embriología Humana
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20191
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Author: Cuadra Blanco, Crótida De La × Subject: 611.013 ×

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    Initial stages of development of the submandibular gland (human embryos at 5.5–8 weeks of development)
    (Journal of Anatomy, 2019) Quirós Terrón, Luis; Arráez Aybar, Luis Alfonso; Murillo González, Jorge Alfonso; Cuadra Blanco, Crótida De La; Martínez Álvarez, María Concepción; Sanz Casado, José Vicente; Mérida Velasco, José Ramón
    The aim of this study was to determine the main stages of submandibular salivary gland development during the embryonic period in humans. In addition, we studied submandibular salivary gland development in rats on embryonic days 14-16 and expression in the submandibular salivary gland region with the monoclonal antibody HNK-1. Serial sections from 25 human embryos with a greatest length ranging from 10 to 31 mm (Carnegie stages 16-23; weeks 5.5-8 of development) and Wistar rats of embryonic days (E) 14-16 were analysed with light microscopy. Five stages of submandibular salivary gland development were identified. The prospective stage (1), between weeks 5.5 and early week 6, is characterized by a thickening of the epithelium of the medial paralingual groove in the floor of the mouth corresponding to the primordium of the submandibular salivary gland parenchyma. At this stage, the primordium of the parasympathetic ganglion lies below the lingual nerve. The primordium of the submandibular salivary gland parenchyma is observed in rats on E14 in the medial paralingual groove with mesenchymal cells, underlying the lingual nerve. These cells are HNK-1-positive, corresponding to the primordium of the parasympathetic ganglion. The bud stage (2), at the end of week 6 in humans and on E15 in rats, is characterized by the proliferation and invagination of the epithelial condensation, surrounded by an important condensation of the mesenchyme. The pseudoglandular stage (3) at week 6.5 is characterized by the beginning of the formation of lobes in the condensed mesenchyme. The canalicular stage (4), between week 7 and 7.5, is characterized by the appearance of a lumen in the proximal part of the submandibular duct. The innervation stage (5) occurs during week 8, with the innervation of the submandibular and interlobular ducts. Nervous branches arriving from the parasympathetic ganglion innervate the glandular parenchyma. Numerous blood vessels are observed nearby. Our results suggest that submandibular salivary gland development requires interactions among epithelium, mesenchyme, parasympathetic ganglion and blood vessels.