Person:
Villanueva Romero, Raúl

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First Name
Raúl
Last Name
Villanueva Romero
URI
https://hdl.handle.net/20.500.14352/86283
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Ciencias Biológicas
Department
Biología Celular
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    Profile of Matrix-Remodeling Proteinases in Osteoarthritis: Impact of Fibronectin
    (Cells, 2019) Pérez García, Selene; Carrión Caballo, Mar; Gutiérrez Cañas, Irene; Villanueva Romero, Raúl; Castro Vázquez, David; Martínez Mora, María Del Carmen; González-Álvaro, Isidoro; Blanco, Francisco J.; Juarranz Moratilla, Yasmina; Pérez Gomáriz, Rosa María
    The extracellular matrix (ECM) is a complex and specialized three-dimensional macromolecular network, present in nearly all tissues, that also interacts with cell surface receptors on joint resident cells. Changes in the composition and physical properties of the ECM lead to the development of many diseases, including osteoarthritis (OA). OA is a chronic degenerative rheumatic disease characterized by a progressive loss of synovial joint function as a consequence of the degradation of articular cartilage, also associated with alterations in the synovial membrane and subchondral bone. During OA, ECM-degrading enzymes, including urokinase-type plasminogen activator (uPA), matrix metalloproteinases (MMPs), and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTSs), cleave ECM components, such as fibronectin (Fn), generating fibronectin fragments (Fn-fs) with catabolic properties. In turn, Fn-fs promote activation of these proteinases, establishing a degradative and inflammatory feedback loop. Thus, the aim of this review is to update the contribution of ECM-degrading proteinases to the physiopathology of OA as well as their modulation by Fn-fs.
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    A Clinical Approach for the Use of VIP Axis in Inflammatory and Autoimmune Diseases
    (International Journal of Molecular Sciences, 2019) Martínez Mora, María Del Carmen; Juarranz Moratilla, Yasmina; Gutiérrez Cañas, Irene; Carrión Caballo, Mar; Pérez García, Selene; Villanueva Romero, Raúl; Castro Vázquez, David; Lamana Domínguez, Amalia; Mellado, Mario; González Álvaro, Isidoro; Pérez Gomáriz, Rosa María
    The neuroendocrine and immune systems are coordinated to maintain the homeostasis of the organism, generating bidirectional communication through shared mediators and receptors. Vasoactive intestinal peptide (VIP) is the paradigm of an endogenous neuropeptide produced by neurons and endocrine and immune cells, involved in the control of both innate and adaptive immune responses. Exogenous administration of VIP exerts therapeutic effects in models of autoimmune/inflammatory diseases mediated by G-protein-coupled receptors (VPAC1 and VPAC2). Currently, there are no curative therapies for inflammatory and autoimmune diseases, and patients present complex diagnostic, therapeutic, and prognostic problems in daily clinical practice due to their heterogeneous nature. This review focuses on the biology of VIP and VIP receptor signaling, as well as its protective effects as an immunomodulatory factor. Recent progress in improving the stability, selectivity, and effectiveness of VIP/receptors analogues and new routes of administration are highlighted, as well as important advances in their use as biomarkers, contributing to their potential application in precision medicine. On the 50th anniversary of VIP’s discovery, this review presents a spectrum of potential clinical benefits applied to inflammatory and autoimmune diseases.