Person:
Villaverde Cantizano, Gonzalo

Profile Picture
First Name
Gonzalo
Last Name
Villaverde Cantizano
URI
https://hdl.handle.net/20.500.14352/77564
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Farmacia
Department
Química en Ciencias Farmacéuticas
Area
Química Física
Identifiers
UCM identifierORCIDScopus Author IDWeb of Science ResearcherIDDialnet IDGoogle Scholar ID

Filters

2011 - 20152
Reset filters

Settings

Author: Villaverde Cantizano, Gonzalo × Has files: false ×

Search Results

Now showing 1 - 2 of 2
  • No Thumbnail Available
    Item
    A new targeting agent for the selective drug delivery of nanocarriers for treating neuroblastoma
    (2015) Villaverde Cantizano, Gonzalo; Baeza, Alejandro ; Melen, Gustavo J. ; Alfranc, Arantzazu ; Ramírez, Manuel ; Vallet Regí, María Dulce Nombre
    Novel targeting agents against neuroblastoma based on the meta-iodobenzylguanidine (MIBG) moiety were synthesized and biologically evaluated for nanocarrier vectorization. These compounds have been anchored on the surface of drug loaded mesoporous silica nanocarriers, resulting in the improved cellular uptake in tumoral cells. Neuroblastoma (NB) is the most frequent extracranial pediatric tumor. Advanced forms of the disease (metastatic and/or refractory) have a dismal prognosis despite the combination of chemotherapy, radiotherapy, surgery and bone narrow transplants. These treatments carry severe side effects and, in some cases, compromise the life of the patient. MIBG has been widely applied in the medical diagnosis of NB due to its affinity for tumor cells through the norepinephrine transporter (NET), which is expressed in 90% of NB tumors. The exclusive accumulation of MIBG in neuroblastoma has been widely studied; however, its properties have been never exploited as a targeting agent in nanocarrier drug delivery systems. Several structural analogues of MIBG have been prepared and attached on the surface of nanocarriers. Their selective internalization has been tested against human neuroblastoma cells, which show, in the best case, cellular uptake four times higher than that of the naked nanosystem. Furthermore, in vivo experiments showed preferential and selective accumulation and retention of the targeted nanosystem comparing with the naked and only PEGylated counterpart systems. This novel nanosystem could be easily applicable to all kinds of drug delivery nanocarriers, providing a universal tool for neuroblastoma chemotherapies that is superior to classical approaches through a novel nanosystem exclusively designed to target this terrible malignancy.
  • No Thumbnail Available
    Item
    Development of homogeneous and heterogenized rhodium(i) and palladium(ii) complexes with ligands based on a chiral proton sponge building block and their application as catalysts
    (2011) Villaverde Cantizano, Gonzalo; Arnanz, Avelina ; Iglesias, Marta ; Monge, Ángeles; Sánchez, Félix ; Snejko, Natalia