Person:
Villaverde Cantizano, Gonzalo

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First Name
Gonzalo
Last Name
Villaverde Cantizano
URI
https://hdl.handle.net/20.500.14352/77564
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Farmacia
Department
Química en Ciencias Farmacéuticas
Area
Química Física
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Now showing 1 - 2 of 2
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    Double sequential encrypted targeting sequence: A new concept for bone cancer treatment
    (Chemistry: a european journal, 2017) Villaverde Cantizano, Gonzalo; Nairi, Valentina; Baeza, Alejandro; Vallet Regí, María Dulce Nombre
    The selective transportation of therapeutic agents to tumoral cells is usually achieved by their conjugation with targeting moieties able to recognize these cells. Unfortunately, simple and static targeting systems usually show selectivity lacks. Herein, double sequential encrypted targeting system is proposed as stimuliresponsive targeting analogue for selectivity enhancement. The system is able to recognize diseased bone tissue in first place, and once there, a hidden secondary targeting group is activated by the presence of an enzyme overproduced in the malignant tissue (cathepsin K), triggering the recognition of diseased cells. Transporting the cell targeting agent in a hidden conformation which contains a high selective tissular primary targeting, could avoid not only its binding to similar cell receptors but also the apparition of the binding-site barrier effect, which can enhance the penetration of the therapeutic agent within the affected zone. This strategy could be applied not only to conjugate drugs but also to drug loaded nanocarriers in order to improve the efficiency for bone cancer treatments.
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    Janus Mesoporous Silica Nanoparticles for Dual Targeting of Tumor Cells and Mitochondria
    (ACS Applied Materials and Interfaces, 2017) López, Victoria; Villegas, Maria Rocio; Rodriguez, Veronica; Villaverde Cantizano, Gonzalo; Lozano Rebollo, Daniel; Baeza, Alejandro; Vallet Regí, María Dulce Nombre
    The development of targeted nanocarriers able to be selectively internalized within tumor cells, and therefore to deliver anti-tumor drugs specifically to diseased cells, constitutes one of the most important goals in nano-oncology. Herein, the development of Janus mesoporous silica particles asymmetrically decorated with two targeting moieties, one of them selective for folate membrane cell receptors (folic acid) and the other one able to bind to mitochondria membrane (triphenylphosphine, TPP), is described in order to achieve sequential cell to organelle vectorization. The asymmetric decoration of each side of the particle allows fine control in the targeting attachment process in comparison with the use of symmetric nanocarriers. The presence of folic acid induces a higher increase in particle accumulation inside tumor cells, and once there, these nanocarriers are guided close to mitochondria by the action of the TPP moiety. This strategy can be applied for improving the therapeutic efficacy of current nanomedicines.