Person: Melero Carrasco, Helena
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First Name
Helena
Last Name
Melero Carrasco
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Psicología
Department
Psicobiología y Metodología en Ciencias del Comportamiento
Area
Psicobiología
Identifiers
3 results
Search Results
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Item Abnormal functional connectivity in radiologically isolated syndrome: A resting-state fMRI study(Multiple Sclerosis Journal, 2023) Benito León, Julián; Pino, Ana Belén del; Aladro, Yolanda; Cuevas, Constanza; Domingo-Santos, Ángela; Galán Sánchez-Seco, Victoria; Labiano-Fontcuberta, Andrés; Gómez-López, Ana; Salgado-Cámara, Paula; Costa-Frossard, Lucienne; Monreal, Enrique; Sainz de la Maza, Susana; Matías-Guiu, Jordi A; Matías-Guiu Guía, Jorge; Delgado Álvarez, Alfonso; Montero-Escribano, Paloma; Martínez-Ginés, María Luisa; Higueras Hernández, Yolanda; Ayuso-Peralta, Lucía; Malpica, Norberto; Melero Carrasco, HelenaBackground: Radiologically isolated syndrome (RIS) patients might have psychiatric and cognitive deficits, which suggests an involvement of major resting-state functional networks. Notwithstanding, very little is known about the neural networks involved in RIS. Objective: To examine functional connectivity differences between RIS and healthy controls using resting-state functional magnetic resonance imaging (fMRI). Methods: Resting-state fMRI data in 25 RIS patients and 28 healthy controls were analyzed using an independent component analysis; in addition, seed-based correlation analysis was used to obtain more information about specific differences in the functional connectivity of resting-state networks. Participants also underwent neuropsychological testing. Results: RIS patients did not differ from the healthy controls regarding age, sex, and years of education. However, in memory (verbal and visuospatial) and executive functions, RIS patients’ cognitive performance was significantly worse than the healthy controls. In addition, fluid intelligence was also affected. Twelve out of 25 (48%) RIS patients failed at least one cognitive test, and six (24.0%) had cognitive impairment. Compared to healthy controls, RIS patients showed higher functional connectivity between the default mode network and the right middle and superior frontal gyri and between the central executive network and the right thalamus ( pFDR < 0.05; corrected). In addition, the seed-based correlation analysis revealed that RIS patients presented higher functional connectivity between the posterior cingulate cortex, an important hub in neural networks, and the right precuneus. Conclusion: RIS patients had abnormal brain connectivity in major resting-state neural networks and worse performance in neurocognitive tests. This entity should be considered not an “incidental finding” but an exclusively non-motor (neurocognitive) variant of multiple sclerosis.Item Abnormal functional connectivity in radiologically isolated syndrome: A resting-state fMRI study(Multiple Sclerosis Journal, 2023) del Pino, Ana Belén; Aladro, Yolanda; Cuevas, Constanza; Domingo-Santos, Ángela; Galán Sánchez-Seco, Victoria; Labiano-Fontcuberta, Andrés; Gómez-López, Ana; Salgado-Cámara, Paula; Costa-Frossard. Lucienne; Monreal. Enrique; Sainz de la Maza, Susana; Montero-Escribano, Paloma; Martínez-Ginés, María Luisa; Higueras, Yolanda; Ayuso-Peralta, Lucía; Malpica, Norberto; Melero Carrasco, Helena; Benito León, Julián; Higueras Hernández, Yolanda; Matías-Guiu Guía, JorgeRadiologically isolated syndrome (RIS) patients might have psychiatric and cognitive deficits, which suggests an involvement of major resting-state functional networks. Notwithstanding, very little is known about the neural networks involved in RIS. Objective: To examine functional connectivity differences between RIS and healthy controls using resting-state functional magnetic resonance imaging (fMRI). Methods: Resting-state fMRI data in 25 RIS patients and 28 healthy controls were analyzed using an independent component analysis; in addition, seed-based correlation analysis was used to obtain more information about specific differences in the functional connectivity of resting-state networks. Participants also underwent neuropsychological testing. Results: RIS patients did not differ from the healthy controls regarding age, sex, and years of education. However, in memory (verbal and visuospatial) and executive functions, RIS patients’ cognitive performance was significantly worse than the healthy controls. In addition, fluid intelligence was also affected. Twelve out of 25 (48%) RIS patients failed at least one cognitive test, and six (24.0%) had cognitive impairment. Compared to healthy controls, RIS patients showed higher functional connectivity between the default mode network and the right middle and superior frontal gyri and between the central executive network and the right thalamus (pFDR < 0.05; corrected). In addition, the seed-based correlation analysis revealed that RIS patients presented higher functional connectivity between the posterior cingulate cortex, an important hub in neural networks, and the right precuneus. Conclusion: RIS patients had abnormal brain connectivity in major resting-state neural networks and worse performance in neurocognitive tests. This entity should be considered not an “incidental finding” but an exclusively non-motor (neurocognitive) variant of multiple sclerosis.Item Relationship between episodic memory and volume of the brain regions of two functional cortical memory systems in multiple sclerosis(Journal of Neurology, 2018) Aladro, Yolanda; López-Alvarez, Laudino; Sánchez-Reyes, Jorge Mario; Hernández-Tamames, Juan Antonio; Rubio-Fernández, Sandra; Thuissard, Israel; Cerezo-García, Marta; Melero Carrasco, Helena