Person:
Guerrero Martínez, Andrés

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First Name
Andrés
Last Name
Guerrero Martínez
URI
https://hdl.handle.net/20.500.14352/76239
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Ciencias Químicas
Department
Química Física
Area
Química Física
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UCM identifierORCIDScopus Author IDWeb of Science ResearcherIDDialnet IDGoogle Scholar ID

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2016 - 201912020 - 20231
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Author: Bañares Morcillo, Luis × Subject: 544 ×

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Now showing 1 - 2 of 2
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    Intracellular pH-Induced Tip-to-Tip Assembly of Gold Nanorods for Enhanced Plasmonic Photothermal Therapy
    (ACS Omega, 2016) Ahijado Guzmán, Rubén; Bañares Morcillo, Luis; Guerrero Martínez, Andrés; López Montero, Iván; Tardajos Rodríguez, Gloria María; González Rubio, Guillermo; Izquierdo, Jesús G.; Calzado Martín, Alicia; Calleja, Montserrat
    The search for efficient plasmonic photothermal therapies using nonharmful pulse laser irradiation at the near-infrared (NIR) is fundamental for biomedical cancer research. Therefore, the development of novel assembled plasmonic gold nanostructures with the aim of reducing the applied laser power density to a minimum through hot-spot-mediated cell photothermolysis is an ongoing challenge. We demonstrate that gold nanorods (Au NRs) functionalized at their tips with a pH-sensitive ligand assemble into oligomers within cell lysosomes through hydrogen-bonding attractive interactions. The unique intracellular features of the plasmonic oligomers allow us to significantly reduce the femtosecond laser power density and Au NR dose while still achieving excellent cell killing rates. The formation of gold tip-to-tip oligomers with longitudinal localized surface plasmon resonance bands at the NIR, obtained from low-aspect-ratio Au NRs close in resonance with 800 nm Ti:sapphire 90 fs laser pulses, was found to be the key parameter for realizing the enhanced plasmonic photothermal therapy.
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    From multi- to single-hollow trimetallic nanocrystals by ultrafast heating
    (Chemistry of Materials, 2023) Manzaneda González, Vanesa; Jenkinson, Kellie; Peña-Rodríguez, Ovidio; Borrell Grueiro, Olivia; Triviño-Sánchez, Sergio; Bañares Morcillo, Luis; Junquera González, María Elena; Espinosa, Ana; González-Rubio, Guillermo; Bals, Sara; Guerrero Martínez, Andrés
    Metal nanocrystals (NCs) display unique physicochemical features that are highly dependent on the nanoparticle dimensions, anisotropy, structure, and composition. The development of synthesis methodologies that allow us to tune such parameters finely emerges crucial for the application of metal NCs in catalysis, optical materials, or biomedicine. Here, we describe a synthetic methodology to fabricate hollow multimetallic heterostructures using a combination of seed-mediated growth routes and femtosecond pulsed laser irradiation. The envisaged methodology relies on the co-reduction of Ag and Pd ions on gold nanorods (Au NRs) to form Au@PdAg core–shell nanostructures containing small cavities at the Au-PdAg interface. The excitation of Au@PdAg NRs with low fluence femtosecond pulses was employed to induce the coalescence and growth of large cavities, forming multihollow anisotropic Au@PdAg nanostructures. Moreover, single-hollow alloy AuPdAg could be achieved in high yield by increasing the irradiation energy. Advanced electron microscopy techniques, energy-dispersive X-ray spectroscopy (EDX) tomography, X-ray absorption near edge structure (XANES) and FDTD (finite differences in the time domain) simulationsallowed us to characterize the morphology, structure, and elemental distribution of the irradiated NCs in detail. The ability of the reported synthesis route to fabricate multimetallic NCs with unprecedented hollow nanostructures brings attractive prospects for the fabrication of tailored high-entropy alloy nanoparticles.