Person: Martínez De La Casa Fernández-Borrella, José María
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First Name
José María
Last Name
Martínez De La Casa Fernández-Borrella
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Óptica y Optometría
Department
Inmunología, Oftalmología y ORL
Area
Oftalmología
Identifiers
10 results
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Item Diagnostic ability of vessel density of the optic nerve head and macula versus structural parameters with optical coherence tomography in pseudoexfoliative glaucoma(Archivos de la Sociedad Española de Oftalmología (English Edition), 2023) Guemes Villahoz, Noemí; Burgos Blasco, B.; Morales-Fernández, L.; Perez García, P.; García Feijoo, Julián; Martínez De La Casa Fernández-Borrella, José MaríaPurpose: To evaluate the diagnostic ability of the vessel density (VD) of the optic nerve head (ONH) and the macula on optical coherence tomography (OCT) angiography and the retinal nerve layer thickness (RNFL) thickness and the macular ganglion cell complex (GCC) thickness on OCT in patients with pseudoexfoliative glaucoma (PXG). Methods: Cross-sectional study including PXG patients and healthy controls. Demographic and clinical data were noted for all participants. Optical coherence tomography (OCT) and OCT angiography (OCTA) images of the ONH and macular area were obtained with the RS-3000 Advance OCT (Nidek Co., Gamagori, Japan). The RNFL and GCC thickness of different sectors was provided by the software. Macular VD of the superficial capillary plexus (SCP) and ONH VD of the radial peripapillary capillary plexus (RPCP) were registered. Groups were compared and area under the receiver operating characteristic (AUROC) curves were used to determine the power of discrimination of each parameter. Results: RNFL and GCC thickness and ONH and macular VD were significantly lower in PXG patients compared with healthy controls (all, p < 0.05). The best discrimination parameter was the average RNFL thickness (AUROC: 0.928). ONH VD AUROC was better than that of macular VD (AUROC: 0.897 and 0.780, respectively). ONH VD AUROC was comparable to RNFL thickness (p < 0.001). Conclusions: The diagnostic ability of ONH vessel density in PXG appears comparable to that of the structural parameters, RNFL and GCC thickness, obtained with OCT, and may be a valuable tool in clinical practice.Item Agreement and clinical comparison between a new swept-source optical coherence tomography-based optical biometer and an optical low-coherence reflectometry biometer(Eye, 2016) Arriola Villalobos, Pedro; Almendral Gómez, Jaime; Garzón Jiménez, Nuria; Ruiz Medrano, J; Fernandez Perez, C; Martínez De La Casa Fernández-Borrella, José María; Díaz Valle, DavidPurpose To compare measurements taken using a swept-source optical coherence tomography-based optical biometer (IOLmaster 700) and an optical low-coherence reflectometry biometer (Lenstar 900), and to determine the clinical impacts of differences in their measurements on intraocular lens (IOL) power predictions. Methods Eighty eyes of 80 patients scheduled to undergo cataract surgery were examined with both biometers. The measurements made using each device were axial length (AL), central corneal thickness (CCT), aqueous depth (AQD), lens thickness (LT), mean keratometry (MK), white-to-white distance (WTW), and pupil diameter (PD). Holladay 2 and SRK/T formulas were used to calculate IOL power. Differences in measurement between the two biometers were determined using the paired t-test. Agreement was assessed through intraclass correlation coefficients (ICC) and Bland–Altman plots. Results Mean patient age was 76.3±6.8 years (range 59–89). Using the Lenstar, AL and PD could not be measured in 12.5 and 5.25% of eyes, respectively, while IOLMaster 700 took all measurements in all eyes. The variables CCT, AQD, LT, and MK varied significantly between the two biometers. According to ICCs, correlation between measurements made with both devices was excellent except for WTW and PD. Using the SRK/T formula, IOL power prediction based on the data from the two devices were statistically different, but differences were not clinically significant. Conclusions No clinically relevant differences were detected between the biometers in terms of their measurements and IOL power predictions. Using the IOLMaster 700, it was easier to obtain biometric measurements in eyes with less transparent ocular media or longer AL.Item A Diagnostic Calculator for Detecting Glaucoma on the Basis of Retinal Nerve Fiber Layer, Optic Disc, and Retinal Ganglion Cell Analysis by Optical Coherence Tomography(Investigative Ophthalmology & Visual Science, 2015) Larrosa Povés, José Manuel; Moreno Montañes, Javier; Martínez De La Casa Fernández-Borrella, José María; Polo Llorens, Vicente; Velázquez Villoria, Álvaro; Berrozpe Villabona, Clara; García Granero, MartaPurpose: The purpose of this study was to develop and validate a multivariate predictive model to detect glaucoma by using a combination of retinal nerve fiber layer (RNFL), retinal ganglion cell-inner plexiform (GCIPL), and optic disc parameters measured using spectral-domain optical coherence tomography (OCT). Methods: Five hundred eyes from 500 participants and 187 eyes of another 187 participants were included in the study and validation groups, respectively. Patients with glaucoma were classified in five groups based on visual field damage. Sensitivity and specificity of all glaucoma OCT parameters were analyzed. Receiver operating characteristic curves (ROC) and areas under the ROC (AUC) were compared. Three predictive multivariate models (quantitative, qualitative, and combined) that used a combination of the best OCT parameters were constructed. A diagnostic calculator was created using the combined multivariate model. Results: The best AUC parameters were: inferior RNFL, average RNFL, vertical cup/disc ratio, minimal GCIPL, and inferior-temporal GCIPL. Comparisons among the parameters did not show that the GCIPL parameters were better than those of the RNFL in early and advanced glaucoma. The highest AUC was in the combined predictive model (0.937; 95% confidence interval, 0.911–0.957) and was significantly (P = 0.0001) higher than the other isolated parameters considered in early and advanced glaucoma. The validation group displayed similar results to those of the study group. Conclusions: Best GCIPL, RNFL, and optic disc parameters showed a similar ability to detect glaucoma. The combined predictive formula improved the glaucoma detection compared to the best isolated parameters evaluated. The diagnostic calculator obtained good classification from participants in both the study and validation groups.Item Fourier domain optical coherence tomography to assess the iridocorneal angle and correlation study in a large Caucasian population(BMC Ophthalmology, 2016) Fernández Vigo, José Ignacio; García Feijoo, Julián; Martínez De La Casa Fernández-Borrella, José María; García Bella, Javier; Arriola Villalobos, Pedro; Fernández Pérez, Cristina; Fernández Vigo, José ÁngelBackground: Recently, novel anatomic parameters that can be measured by optical coherence tomography (OCT), have been identified as a more objective and accurate method of defining the iridocorneal angle. The aim of the present study is to measure the iridocorneal angle by Fourier domain (FD) OCT and to identify correlations between angle measurements and subject factors in a large healthy Caucasian population. Methods: A cross sectional study was performed in 989 left eyes of 989 healthy subjects. The iridocorneal angle measurements: trabecular-iris angle (TIA), angle opening distance (AOD500) and trabecular-iris space area (TISA500) 500 μm from the scleral spur, were made using the FD-OCT RTVue®. Iris thickness was also measured. Correlations were examined between angle measurements and demographic and ocular factors. The main determinants of angle width were identified by multivariate linear regression. Results: TIA could be measured in 94 % of the eyes, and AOD500 and TISA500 in 92 %. The means recorded were TIA 35.8 ± 12.2 degrees (range 1.5 to 76.1), AOD500 542.6 ± 285.4 μm (range 15 to 1755), and TISA500 0.195 ± 0.104 mm2 (range 0.02 to 0.62). The correlation between the temporal and nasal quadrant was R = 0.902 for TIA. The reproducibility of measurements was excellent (intraclass correlation coefficient >0.947). Mean angle width measurements were smaller in women (p = 0.02). Correlation was detected between angle means and anterior chamber volume (ACV; R = 0.848), anterior chamber depth (ACD; R = 0.818), spherical error (R = -0.619) and age (R = -0.487), while no correlation was observed with Intraocular pressure (R = -0.052). ACV emerged as the main determinant of TIA (R2 = 0.705; p < 0.001). Conclusions: In this Caucasian population, strong correlation was detected between FD-OCT anterior angle measurements and ACV, ACD, spherical refractive error and sex, emerging the ACV as the main determinant of TIA.Item Identificación de estructuras del ángulo iridocorneal mediante tomografía de coherencia óptica de dominio Fourier(Archivos de la Sociedad Española de Oftalmología, 2016) Fernández Vigo, José Ignacio; Fernández Vigo, Cristina; Martínez De La Casa Fernández-Borrella, José María; Sáenz Francés, Federico; Santos Bueso, Enrique Miguel; García Feijoo, Julián; Fernández Vigo, José ÁngelObjetivo: estudiar las estructuras que conforman el ángulo iridocorneal mediante tomografía de coherencia óptica (OCT) de segmento anterior, definiendo sus características tomográficas y cuantificando su frecuencia de identificación. Material y métodos: estudio transversal realizado en 267 ojos derechos de 267 pacientes consecutivos sanos. Se empleó una OCT de dominio Fourier RTVue (Optovue Inc, CA, EE. UU.) para explorar el ángulo iridocorneal en los sectores nasal y temporal. Las estructuras evaluadas fueron: el limbo externo, transición corneoescleral, línea de Schwalbe, malla trabecular, canal de Schlemm, espolón escleral y receso angular. Se calculó la concordancia intra- e interobservador para la identificación de las estructuras mediante el coeficiente kappa. Resultados: la edad media fue 41,3 ± 14,3 años (rango 20-80); el 57% eran mujeres. El limbo externo, la transición córneo-escleral y la línea de Schwalbe se identificaron en un 98,7; 97 y 93,4%, respectivamente de las imágenes. La malla trabecular y el canal de Schlemm se identificaron en el 91% de los casos. El espolón escleral pudo ser identificado en un 85,4% y el receso angular en un 74,5%. No existió diferencia en la identificación entre el sector temporal y nasal. La concordancia intra- e interobservador fue de k=0,92 y k=0,88 respectivamente, en la identificación de las estructuras para el total de las imágenes estudiadas. Conclusiones: la OCT de dominio Fourier es una técnica eficaz para la identificación de las estructuras que conforman el ángulo iridocorneal, entre las que destacan la malla trabecular, el canal de Schlemm, el espolón escleral y la línea de Schwalbe.Item Morphometry of the trabecular meshwork in vivo in a healthy population using fourier-domain optical coherence tomography(Investigative Ophthalmology & Visual Science, 2015) Fernández Vigo, José Ignacio; García Feijoo, Julián; Martínez De La Casa Fernández-Borrella, José María; García Bella, Javier; Fernández Vigo, José ÁngelPURPOSE. We measured the length, thickness, and area of the trabecular meshwork (TM) in vivo using Fourier domain optical coherence tomography (FD-OCT) in a Caucasian population of healthy subjects. METHODS. A cross-sectional study was done of 1006 healthy subjects. Left eyes were randomly selected. Age, sex, IOP, and spherical refractive error were noted. The depth and volume of the anterior chamber and the central corneal thickness were measured with Pentacam, while IOL Master was used to measure the axial length. The length, thickness, and area of the TM were measured through FD-OCT RTVue. A study was done to determine the correlation between TM size, and other demographic and ocular parameters. Finally, the reproducibility of the measurements was assessed for a subgroup of 50 eyes from 50 patients. RESULTS. We were able to measure the TM in 91.1% of the total eyes studied. The mean TM length was 496.99 6 92.77 lm (range, 275–800), TM thickness was 174.16 6 28.14 lm (range, 100–276), and TM area was 0.069 6 0.031 mm2 (range, 0.023–0.133). No differences were found in terms of length and area for sex, although the TM was slightly thicker in men (P ¼ 0.046). No correlation was observed between the TM measurements and any of the studied demographic or ocular parameters (R < 0.09, P < 0.001). Intra- and interobserver reproducibility of the measurements were good (intraclass correlation coefficient > 0.750, P < 0.001). CONCLUSIONS. The FD-OCT is an effective and reproducible examination technique to measure the length, thickness, and area of the TM in vivo.Item Reproducibility of peripapillary, optic nerve head and macular vessel density by OCT-A according to glaucoma severity staging(Archivos de la Sociedad Española de Oftalmología (English Edition), 2023) Salazar Quiñones, Liseth; Peña Urbina, Pilar; Fernández Vigo, José Ignacio; Pérez Quiñones, Y.; Molero Senosiain, Mercedes; Méndez Hernández, Carmen Dora; Martínez De La Casa Fernández-Borrella, José María; García Feijoo, JuliánObjective: To assess the reproducibility of peripapillary, optic nerve head (PP-ONH) and macular vessel density (VD) by Spectral Domain optical coherence tomography angiography (SD OCT-A) in glaucoma patients and healthy subjects. Methods: Cross-sectional study assessing 63 eyes of 63 subjects, including 33 glaucoma patients and 30 healthy subjects. Glaucoma was classified in mild, moderate, or advanced. Two consecutive scans were acquired by Spectralis Module OCT-A (Heidelberg, Germany), and provided images of the superficial vascular complex (SVC), nerve fiber layer vascular plexus (NFLVP), superficial vascular plexus (SVP); deep vascular complex (DVC), intermediate capillary plexus (ICP) and deep capillary plexus (DCP). VD (%) was calculated by AngioTool. Intraclass correlation coefficients (ICCs) and coefficients of variation (CV) were calculated. Results: Among PP-ONH VD, better ICC presented advanced (ICC 0.86–0.96) and moderate glaucoma (ICC 0.83–0.97) compared with mild glaucoma (0.64−0.86). For the macular VD reproducibility, ICC results for superficial retinal layers were better for mild glaucoma (0.94−0.96) followed by moderated (0.88−0.93) and advanced glaucoma (0.85−0.91), and for deeper retinal layers ICC was better for moderate glaucoma (0.95–0.96) followed by advanced (0.80−0.86) and mild glaucoma (0.74−0.91). CVs ranged from 2.2% to 10.94%. Among healthy subjects, ICCs for the PP-ONH VD measurements (0.91−0.99) and for the macular VD measurements (0.93−0.97) were excellent in all layers, with CVs from 1.65% to 10.33%. Conclusions: SD OCT-A used to quantify macular and PP-ONH VD showed excellent and good reproducibility in most layers of the retina, both in healthy subjects and in glaucoma patients regardless of the severity of the disease.Item Update on the usefulness of optical coherence tomography in assessing the iridocorneal angle(Archivos de la Sociedad Española de Oftalmología, 2019) Kudsieh, Bachar; Fernández Vigo, José Ignacio; Vila Arteaga, Jorge; Aritz Urcola, Javier; Martínez De La Casa Fernández-Borrella, José María; García Feijoo, Julián; Ruiz Moreno, José María; Fernández Vigo, José ÁngelThe iridocorneal angle, due to its implications in the physiopathology of aqueous humour drainage, is a fundamental structure of the anterior chamber. Anterior segment optical coherence tomography (AS−OCT) is a rapid and non-invasive technique that obtains images in vivo. The high resolution allows it to analyse the normal anatomy of the angle, any alterations, and the changes that occur after different therapeutic interventions. AS−OCT technology has evolved to provide images that allow the identification and quantification of the angular structures in healthy subjects and in glaucoma patients, and especially the trabecular meshwork and the Schlemm's canal. It also enables the angle width to be quantified, with some objective parameters that have been standardised in recent years, such as the trabecular-iris angle (TIA), the angle opening distance (AOD), and the trabecular-iris area (TISA). This technique has multiple uses in the study of the different mechanisms of angle closure, the evaluation of changes after a laser peripheral iridotomy or iridoplasty after cataract surgery, as well as after the implantation of phakic lenses.Item Ocular Surface Disease in Patients under Topical Treatment for Glaucoma(European Journal of Ophthalmology, 2018) Pérez Bartolomé, Francisco; Martínez De La Casa Fernández-Borrella, José María; Arriola Villalobos, Pedro; Fernández Pérez, Cristina; Polo Llorens, Vicente; García Feijoo, JuliánPurpose: To examine the relationship between ocular surface disease (OSD) and topical antiglaucoma therapy. Methods: A total of 211 eyes of 211 patients with open-angle glaucoma or ocular hypertension on topical medication were recruited over 10 months. Controls were 51 eyes of 51 healthy age- and sex-matched volunteers. In each patient, we recorded the intraocular pressure-lowering eyedrops used, the number of medications used, and daily and cumulative preservative concentrations (PC). Main outcome measures were fluorescein corneal staining score (Oxford scale), lower tear meniscus height (LTMH) (spectral-domain optical coherence tomography), noninvasive tear film breakup time (NI-TBUT) (Oculus Keratograph 5M), and OSD symptom questionnaire index (OSDI). Results: Compared to controls, significantly higher OSDI (median [interquartile range] 10.24 [4.54-18.94] vs 2.5 [0-12.5]; p<0.001) and corneal staining (≥1: 64.93% vs 32.61%; p<0.001) scores were recorded in the medication group. The NI-TBUT and LTMH failed to vary between the groups (p>0.05). A higher daily PC was associated with a lower LTMH (R −0.142; p = 0.043). In the medication group, multivariate analysis identified correlations between benzalkonium chloride (BAK) (odds ratio [OR] 1.56) and BAK plus polyquaternium-containing drops (OR 5.09) or higher OSDI (OR 1.06) and abnormal corneal staining test results and between older age (mean ratio [MR] 1.05), longer treatment duration (MR 1.02), or corneal staining presence (MR 1.22) and a higher OSDI score. Conclusions: Ocular surface disease was more prevalent in the medication group. The main factors impacting OSD were drops with preservatives, longer treatment duration, and older age.Item Normative database for separate inner retinal layers thickness using spectral domain optical coherence tomography in Caucasian population(PLoS ONE, 2017) Nieves Moreno, María; Martínez De La Casa Fernández-Borrella, José María; Cifuentes Canorea, Pilar; Sastre Ibáñez, Marina; Santos Bueso, Enrique Miguel; Sáenz Francés, Federico; Morales Fernández, Laura; García Feijoo, JuliánPurpose: Develop the first normative database of the thickness of every inner retinal layer in the macular area in a healthy, Caucasian population between 18 to 87 years old, using Spectralis Optical Coherence Tomography (OCT). Methods: On this transversal, observational study, 300 patients between 18 to 87 years old and without an ophthalmological condition were recruited. Macular OCT scans were performed on all patients (Spectralis OCT, Heidelberg Engineering). An axial length measurement, and keratometry were performed using an optical biometer. The volume and thickness of the different macular sectors of the inner retinal layers (retinal nerve fiber layer (RNFL), ganglion cells layer (CGL) and inner plexiform layer (IPL)) were analyzed with the Spectralis OCT segmentation software. An eye was randomly selected for each patient. Results: 297 patients (179 females and 118 males) were included in the study. The mean age was 56.07 years (range: 40.50-72). The multivariate analysis showed a positive correlation between the RNFL thickness and the axial length (p < 0.001). The mean central retinal thickness was 278.2 Mm (range: 266-291), the mean central RNFL thickness was 12.61 Mm (range: 11-14), the mean central CGL thickness was 17.63 Mm (range: 14-21) and the mean central IPL thickness was 22.02 Mm (range: 20-25). The multivariate analysis showed a negative correlation between age and CGL thickness and inner IPL thickness (p< 0.001). Conclusion: This study provides a normative database of the volume of each of the inner retinal layers on a Caucasian population.