Person:
Michalska Dziama, Patrycja

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First Name
Patrycja
Last Name
Michalska Dziama
URI
https://hdl.handle.net/20.500.14352/87162
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Farmacia
Department
Química en Ciencias Farmacéuticas
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Author: Almale Del Barrio, Laura ×

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    Novel Multitarget Hybrid Compounds for the Treatment of Alzheimer’s Disease
    (Current Topics in Medicinal Chemistry, 2016) Michalska Dziama, Patrycja; Buendia, Izaskun; Almale Del Barrio, Laura; León Martínez, Rafael
    Alzheimer's disease (AD) is the most prevalent among the aging diseases known as neurodegenerative disorders. Drug design programs over the last two decades were mainly based on the cholinergic, the amyloid or the tau hypothesis. However, none of the new drugs have a real impact on the outcome of the disease. The complex nature of AD has led to new approaches for drug development programs, the multitarget drug design hypothesis. Based on this hypothesis, the generation of multitarget hybrid compounds from previously known active molecules has been one of the most widely used to obtain new candidates for the future treatment of AD. Here, we summarize recent developments based on the hybridization hypothesis to obtain a potential clinical candidate for AD.