Person:
Bosch López, Jaime Alfonso

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First Name
Jaime Alfonso
Last Name
Bosch López
URI
https://hdl.handle.net/20.500.14352/85384
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Veterinaria
Department
Sanidad Animal
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2016 - 20172
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Start date: 2010 × Subject: 597.6 ×

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Now showing 1 - 2 of 2
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    Heritability of Batrachochytrium dendrobatidis burden and its genetic correlation with development time in a population of Common toad (Bufo spinosus)
    (Evolution: International Journal of Organic Evolution, 2016) Palomar García, Gemma; Cano, Jose Manuel; Bosch López, Jaime Alfonso
    Despite the important threat that emerging pathogens pose for the conservation of biodiversity as well as human health, very little is known about the adaptive potential of host species to withstand infections. We studied the quantitative genetic architecture responsible for the burden of the fungal pathogen Batrachochytrium dendrobatidis in a population of common toads in conjunction with other life-history traits (i.e., body size and development rate) that may be affected by common selective pressures. We found a significant heritable component that is associated with fungal burden, which may allow for local adaptation to this pathogen to proceed. In addition, the high genetic correlation found between fungal burden and development time suggests that both traits have to be taken into account in order to assess the adaptive response of host populations to this emerging pathogen.
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    Early exposure to Batrachochytrium dendrobatidis causes profound immunosuppression in amphibians
    (European Journal of Wildlife Research, 2017) Fernández-Loras, Andrés; Fernández-Beaskoetxea, Saioa; Arriero Higueras, Elena; Fisher, Matthew C.; Bosch López, Jaime Alfonso
    Fungal pathogens have evolved a broad suite of strategies aiming at evading the host immune response. Amphibians are globally infected by the panzootic chytrid fungus Batrachochytrium dendrobatidis (Bd) and, while robust innate immune defences have been characterised, there is little evidence for the existence of effective adaptive immunity. We determine the immune response of the common midwife toad following challenge by Bd as larvae. Immune function was described for both the cell-mediated and antibody-mediated immune responses following infectious challenge as larval amphibians. While there were no significant differences in the ratio of neutrophils/lymphocytes between infected and uninfected individuals, early exposure of tadpoles to Bd significantly dampened the levels of circulating immunoglobulins (IgM and IgY) in the serum of juveniles after metamorphosis. Our results show that Bd immunosuppresses amphibians when infection occurs as larvae with potentially broad effects on the remodelling of immunity during metamorphosis.