Person:
Garzón Jiménez, Nuria

First Name

Nuria

Last Name

Garzón Jiménez

URI

https://hdl.handle.net/20.500.14352/79975

Affiliation

Universidad Complutense de Madrid

Faculty / Institute

Óptica y Optometría

Department

Optometría y Visión

Area

Optica

Identifiers

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Now showing 1 - 10 of 29

Biomechanical Stability of Three Intraocular Lenses With Different Haptic Designs: In Silico and In Vivo Evaluation
(Journal of Refractive Surgery, 2020) Laura Remón; Iulen Cabeza-Gil; Begoña Calvo; Francisco Poyales; Nuria Garzón; Garzón Jiménez, Nuria
Purpose: To assess the biomechanical stability of three different marketed intraocular lenses (IOLs) with different haptic designs (four-loop IOL [Micro F FineVision model] and double C-loop IOL [POD F and POD FT models], all manufactured by PhysIOL), in silico (computer simulation) and in vivo (in the context of lens surgery). Methods: An in silico simulation investigation was performed using finite element modeling (FEM) software to reproduce the compression test defined by the International Organization for Standardization and in vivo implantation in patients in the context of lens surgery was evaluated 1 day and 3 months postoperatively. IOL decentration and rotation were tested. In addition, the stress and strains were analyzed with the finite element method. Results: In the in silico evaluation, the compression force for the POD F IOL was slightly lower than for the POD FT IOL and Micro F IOL for all compression diameters. The axial displacement was maximum for the POD FT IOL and the tilt, rotation, and lateral decentration were substantially lower than the acceptable tolerance limits established in ISO 11979-2. In the in vivo evaluation, a total of 45 eyes from 45 patients were selected, 15 eyes for each IOL model under assessment. Statistically significant differences were found between the Micro F and POD F IOLs for lateral decentration in the x-direction (in absolute value) at 3 months postoperatively (P = .03). Conclusions: Although statistically significant differences have been found when comparing the displacement, tilt, and rotation between the different lenses, these differences cannot be considered clinically relevant, which would suggest that all three IOL models yield excellent stability in those terms. FEM appears to be a powerful tool for numerical studies of the biomechanical properties of IOLs. [J Refract Surg. 2020;36(9):617-624.]
Comparison of visual performance between two aspheric monofocal intraocular lens models
(Clinical and Experimental Optometry, 2021) Poyales Galán, Francisco; Garzón Jiménez, Nuria; Zhou, Ying; Millán García Varela, María Sagrario; Vega Lerin, Fidel
Clinical relevance: It is important to distinguish between visual acuity, optical quality and quality of vision when outcomes obtained with intraocular lenses are evaluated. These parameters, that include objective and subjective tests, should be assessed to obtain results that is not biased. Background: To assess the difference in visual and optical quality between two monofocal intraocular lens models. Methods: : This was a prospective, parallel and randomised clinical study conducted at Miranza IOA, a private clinic in Madrid, Spain. Sixty patients were implanted bilaterally, 30 per group, with two aspheric IOLs with induced spherical aberration of −0.27 μm for Group A and −0.20 μm for Group B. Visual outcomes obtained at 1 and 3 months after surgery included both uncorrected (UCVA) and corrected monocular distance visual acuity (DCVA), objective scattering index (OSI), modulation transfer function (MTF) cut-off, Strehl Ratio (SR), contrast sensitivity defocus curve (CSDC), intraocular lens spherical aberration (SA), and longitudinal chromatic aberration of the eye. Activity limitations in daily life was assessed using CatQuest-9SF questionnaire. Results: There were statistically significant differences for DCVA (004 LogMAR; p = .008) and SR (0.03;p = .003) between groups. Outcomes related to CSDC showed statistically significant differences for vergences between −0.50 D and +1.00 D (3mmpupil) and for vergences of 0.00 D and +0.50 D (4.5 mm pupil) between groups. Overall, Group A showed better results regarding visual and optical quality, including a lower longitudinal chromatic aberration result in comparison to Group B. Patient satisfaction evaluated with CatQuest-9SF showed that Group A achieved better outcomes, although the differences were statistically significant only for the ‘Reading text on television’ item (p = 0.027). Conclusions: Both intraocular lens models showed excellent quantity of vision, optical and visual quality as well as high patient satisfaction. Despite this, the the Group A model provided slightly better outcomes than the Group B model.
Optical Behavior of an Enhanced Monofocal Intraocular Lens Compared with a Standard One
(Applied Sciences, 2023) Albarrán Diego, César; García Montero, María; Garzón Jiménez, Nuria; González Fernández, Verónica; Gómez Pedrero, José Antonio
The aim of this work was to compare an enhanced monofocal (RayOne EMV RAO200E, Rayner) and standard monofocal (RayOne RAO600C Aspheric, Rayner) intraocular lenses (IOLs) for three nominal powers (+10.00 D, +20.00 D and +30.00 D) as a function of the optical aperture diameter (pupil diameter) using a commercial Schlieren phase-shifting deflectometer NIMO TR1504 (Lambda-X, Belgium). From the wavefront maps measured by this instrument, the radial power profiles, the spherical aberration coefficients of the Zernike polynomial expansion (as a function of the optical aperture radius), and the root-mean-square (RMS) of the high-order aberrations (HOAs) were obtained and analyzed by comparing the two models. The results showed that the effective added power that could be obtained with the enhanced model depended directly on the pupil size and the power of the IOL implanted. The higher additions were achieved with the higher nominal IOL powers. The relationship between the pupil diameter, the corneal aberration of the patients and the power profile of these IOLs could have a crucial implication on the far distance and the final effective addition. However, it is important to note that these findings should be clinically validated through the implantation of these models in patients’ lenses.
Comparison of 3-month visual outcomes of a spherical and a toric trifocal intraocular lens
(Journal of Cataract & Refractive Surgery, 2018) Poyales Galán, Francisco; Garzón Jiménez, Nuria
Purpose: To evaluate visual outcomes and satisfaction after implantation of 2 trifocal intraocular lenses (IOLs): a spherical IOL and a toric IOL. Setting: IOA Madrid Innova Ocular, Madrid, Spain. Design: Prospective, controlled clinical trial. Methods: Patients (>50 years) were implanted bilaterally with either a trifocal spherical hydrophilic IOL (FineVision POD F) if corneal astigmatism was 1.0 diopter (D) or less, or with a trifocal toric hydrophilic IOL (FineVision POD FT) if astigmatism was more than 1.0 D. Outcomes analyzed 3 months after surgery included monocular and binocular visual acuities at distance, near, and intermediate, both uncorrected and corrected. Defocus curves, contrast sensitivity, and patient satisfaction were also assessed. Results: There was no statistically significant difference between groups in monocular uncorrected distance (UDVA) (P = .38), monocular corrected distance (CDVA) (P = .22), or distance-corrected intermediate (DCIVA) (P = .95) visual acuities; however, the distance-corrected near visual acuity (DCNVA) was slightly better in the spherical IOL group (P = .008). The UDVA was 20/25 or better in 89% of eyes in the spherical IOL group and 93% in the toric IOL group. The DCIVA was 20/32 or better in 92% of eyes in the spherical IOL group and 93% in the toric IOL group at 80 cm (Radner Vissum chart), and 20/32 or better in 100% of eyes in both groups at 63 cm (Colenbrander chart). The DCNVA (Radner chart) was 20/32 or better in 89% of eyes in the spherical IOL group and 90% of eyes in the toric IOL group. There was no difference between the groups in contrast sensitivity, defocus curves, cylinder, or satisfaction results. Conclusion: Patients had significant improvement in visual acuity and gained functional uncorrected visual acuity across all distances in both groups. Satisfaction was high with both IOLs.
Visual acuity of pseudophakic patients predicted from in-vitro measurements of intraocular lenses with different design
(Biomed Opt Express, 2018) Fidel Vega; Maria Sagrario Millán; Nuria Garzón; Irene Altemir; Francisco Poyales; Jose Manuel Larrosa; Garzón Jiménez, Nuria
The optical quality of a set of IOLs (modeling set: one monofocal and two bifocals) was assessed through focus by the area under the modulation transfer function (MTFa) metric and related to the visual acuity (VA) defocus curves of pseudophakic patients implanted with said IOLs. A non-linear relationship between the MTFa and clinical VA was obtained with an asymptotic limit found to be the best VA achievable by the patients. Two mathematical fitting functions between clinical VA and MTFa were derived with high correlation coefficients (R2≥0.85). They were applied to the MTFa obtained from a different set of IOLs with advanced designs (trial set: one extended range of vision -ERV-, one trifocal ERV and one trifocal apodized) to predict VA versus defocus of patients implanted with these IOLs. Differences between the calculated VA and the clinical VA for both fitting models were within the standard deviation of the clinical measurements in the range of -3.00 D to 0.00 D defocus, thus proving the suitability of the MTFa metric to predict clinical VA performance of new IOL designs.
Clinical assessment of chromatic aberration in phakic and pseudophakic eyes using a simple autorefractor
(Biomedical Optics Express, 2019) Millán García Varela, María Sagrario; Vega Lerin, Fidel; Poyales Galán, Francisco; Garzón Jiménez, Nuria
We describe a psychophysical method and a simple setup – an autorefractor with a Scheiner disc, sequentially illuminated with red and blue lights – for the clinical assessment of the longitudinal chromatic aberration (LCA) in phakic and pseudophakic patients. This method applies to the unaccommodated eye, even in the presence of positive or negative refractive errors and astigmatism. It measures the chromatic difference of refraction as an estimate of LCA. We built a proof of concept from inexpensive and off-the-shelf optomechanical components with which we obtained the preliminary clinical results presented in the paper. We considered one control group of phakic patients and three groups of pseudophakic patients with monofocal implants of different designs and materials. The results, satisfactory and consistent with those reported by other researchers in related works, demonstrate the method and system feasibility.
Changes in Accommodative and Binocular Function following Phakic Intraocular Lens for High and Low-to-Moderate Myopia
(International Journal of Environmental Research and Public Health, 2022) López Artero, Esther; Poyales Galán, Francisco; Garzón Jiménez, Nuria; Matamoros Hondarza, Alicia; Sáenz, Alba; Zhou, Ying; García Montero, María
settingsOrder Article Reprints Open AccessArticle Changes in Accommodative and Binocular Function following Phakic Intraocular Lens for High and Low-to-Moderate Myopia by Esther López-Artero 1ORCID,Francisco Poyales 1,Nuria Garzón 1,2ORCID,Alicia Matamoros 1,Alba Sáez 1,Ying Zhou 3ORCID andMaría García-Montero 1,2,* 1 Miranza Group, C/Galileo 104, 28003 Madrid, Spain 2 Optometry and Vision Department, Faculty of Optics and Optometry, Complutense University of Madrid, 28037 Madrid, Spain 3 OCULUS Iberia, S.L., Tres Cantos, 28760 Madrid, Spain * Author to whom correspondence should be addressed. Int. J. Environ. Res. Public Health 2022, 19(11), 6716; https://doi.org/10.3390/ijerph19116716 Received: 27 April 2022 / Revised: 27 May 2022 / Accepted: 28 May 2022 / Published: 31 May 2022 Download Versions Notes Abstract The aim was to evaluate accommodative and binocular function of phakic intraocular lens implantable collamer lens (ICL) in high and low-to-moderate myopia. Prospective comparative cohort study with 38 myopic patients who underwent ICL implantation were divided into two groups of 19 patients, each one based on the spherical equivalent (SE): high-power (SE ≤ −6 D) and low-to-moderate (SE > −6 D). The push-up amplitude of accommodation (AA), monocular accommodative facility (MAF), distance and near ocular deviation, near convergence amplitude, near point convergence (NPC), stereopsis, and accommodative convergence/accommodation (AC/A) ratio were assessed before surgery and 1 week and 1 month postoperatively. The mean residual refractive error at 1 month after surgery improved in both groups, 0.18 ± 0.34 D and 0.09 ± 0.26 D, respectively (p < 0.001). There was a significant decrease in AA in both groups between preoperatively and at 1-week (p = 0.001; p = 0.008, respectively) and 1-month follow-up (p = 0.001; p = 0.008). For the rest of the binocular measurements, no statistically significant postoperative changes were found in any group. This finding suggests follow-up studies on amplitude of accommodation in phakic intraocular lens ICL implantation.
Influence of isofocal intraocular lenses on objective refraction based on autorefraction and aberrometry
(Graefe's Archive for Clinical and Experimental Ophthalmology, 2023) Pérez Sanz, Lidia María; Charbel, Carla; Poyales Galán, Francisco; Garzón Jiménez, Nuria
Purpose: To evaluate and compare the objective refractions obtained by autorefraction and aberrometry under different lighting conditions with an isofocal intraocular lens (Isopure, BVI medical, Liége, Belgium) compared to a monofocal control lens (Micropure, BVI medical, Liége, Belgium) with the same platform and material. Methods: Prospective, comparative and randomized study on patients undergoing cataract surgery and bilateral isofocal or monofocal IOL implantation. A total of 44 subjects were randomly assigned to either the isofocal group (n = 22) or the Micropure (n = 22). Manifest refraction (MR) was always performed under the same lighting conditions for all the patients. For objective refraction the autorefractor KR8800 and the aberrometer OPD-Scan III (Nidek Inc., Tokyo, Japan.) were used. For each eye included in the study, six result sets were collected: MR, AR (autorefraction measured with the autorefractor), WF-P and WF-M (Zernike-coefficients-based objective refraction, photopic and mesopic pupil size), OPD-C and OPD-M (autorefraction measured with the aberrometer in photopic and mesopic conditions). Results The mean sphere for MR was 0.03 ± 0.32D for the Isopure group and 0.24 ± 0.22D for the monofocal group (p = 0.013). For the Isopure group, Friedman analysis showed statistically significant differences for sphere measured with WF-P (p = 0.035), WF-M (p = 0.018) and OPD-M (p = 0.000), and SE measured with OPD-M (p = 0.004). In the Micropure lens group, the Friedman analysis showed differences for all values studied (p < 0.05). Correlation coefficients showed that AR is the objective method with the strongest correlation values for all components of refraction for both groups. Conclusion: The modification of the surfaces of the isofocal lens does not have a negative impact on the refraction obtained by AR compared to a standard monofocal intraocular lens.
Visual and Refractive Outcomes after Bilateral Implantation of an Enhanced Monofocal IOL: a Prospective study.
(Journal of Cataract & Refractive Surgery, 2024) García Bella, Javier; Burgos Blasco, Bárbara; Vidal Villegas, Beatriz; Garzón Jiménez, Nuria; Villanueva Gómez-Chacón, Celia; García Feijoo, Julián
Purpose: To evaluate visual and refractive outcomes, as well as patient satisfaction after bilateral implantation of an enhanced monofocal intraocular lens (IOL) with emmetropia as a target refraction. Setting: San Carlos Hospital, Madrid, Spain. Design: Prospective, monocentric, non-comparative study. Methods: Adults 21 years or older suitable for cataract surgery and with corneal astigmatism < 1.50D were bilaterally implanted with the RayOne EMV IOL and followed up for 3-months. Outcomes measures included refraction, monocular and binocular uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), uncorrected intermediate visual acuity (UIVA), distance corrected intermediate visual acuity (DCIVA), and defocus curve, aberrometry, and satisfaction. Visual symptoms were assessed using the CatQuest-9SF questionnaire. Results: 50 eyes of 25 patients were included. At Month-3, the mean manifest spherical equivalent was -0.39 ± 0.28 D, with all eyes within 1.00 D. Binocularly, uncorrected, at distance, 68% of patients could read ≤ 0.0 logMAR and 95% ≤ 0.2 logMAR; at intermediate 59% of patients could read ≤0.1 and 100% ≤ 0.2 logMAR. Mean monocular CDVA was -0.03 ± 0.06 logMAR and mean monocular DCIVA was 0.28 ± 0.07 logMAR. Binocular defocus curve demonstrated a visual acuity ≤ 0.2 logMAR over a 2 D range from +1.00 D to -1.25 D. Satisfaction was good in 96% of patients. Conclusion: Bilateral implantation of an enhanced monofocal IOL with emmetropia as a target provided excellent binocular CDVA and good DCIVA, with a high level of satisfaction.
Pre-operative simulation of post-operative multifocal vision
(Biomedical Optics Express, 2019) Maria Viñas; Sara Aissati; Mercedes Romero; Clara Benedi-Garcia; Nuria Garzon; Francisco Poyales; Carlos Dorronsoro; Susana Marcos; Garzón Jiménez, Nuria
While multifocal intraocular lenses (MIOLs) are increasingly implanted to correct for presbyopia, how one sees with a multifocal correction is hard to explain and imagine. The current study evaluates the quality of various visual simulating technologies by comparing vision with simulated MIOLs pre-operatively and the implanted MIOLs post-operatively in the same patients. Two simulation platforms were used: (1) a custom-developed adaptive optics (AO) system, with two visual simulator devices: a spatial light modulator (SLM) and an optotunable lens operating under temporal multiplexing (SimVis); and (2) a wearable, binocular, large field of view SimVis2Eyes clinical simulator (SimVis Gekko, 2Eyes Vision, Madrid, Spain). All devices were programmed to simulate a trifocal diffractive MIOL (POD F, FineVision, PhysIOL). Eight patients were measured pre-operatively simulating the trifocal lens and post-operatively with implantation of the same MIOL. Through-focus decimal visual acuity (TF VA) was measured (1) monocularly in monochromatic light using a four-alternative-forced-choice procedure in the AO system, and (2) binocularly using a clinical optotype in white light. Visual simulations pre-operatively predict well the TF VA performance found post-operatively in patients implanted with the real IOL. The average RMS difference between TF curves with the different visual simulators was 0.05 ± 0.01. The average RMS difference between the TF VA curves with the SimVis pre-operatively and the real MIOL post-operatively was 0.06 ± 0.01 in both platforms, and it was higher in cataract eyes (0.08 ± 0.01, on average across simulators) than in eyes with clear lens. In either group, the shape of the TF curves is similar across simulators and pre-and post-operatively. TF curves cross-correlated significantly between simulators (lag k = 0, rho = 0.889), as well as with results with the real MIOL implanted (lag k = 0, rho = 0.853). Visual simulations are useful programmable tools to predict visual performance with MIOLs, both in an AO environment and in a clinical simulator. Pre-operative visual simulations and post-operative data are in good agreement.