Person:
Cortés Gardyn, Óscar

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First Name
Óscar
Last Name
Cortés Gardyn
URI
https://hdl.handle.net/20.500.14352/80452
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Veterinaria
Department
Producción Animal
Area
Producción Animal
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2018 - 20192
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Author: Eusebi, Paulina ×

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Now showing 1 - 2 of 2
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    Detection of selection signatures for agonistic behaviour in cattle
    (Journal of Animal Breeding and Genetics, 2018) Eusebi, Paulina; Cortés Gardyn, Óscar; Carleos, Carlos; Dunner Boxberger, Helene Susana; Cañón Ferreras, Francisco Javier
    The identification of genomic regions including signatures of selection produced by domestication and its subsequent artificial selection processes allows the understanding of the evolution of bovine breeds. Although several studies describe the genomic variability among meat or milk production cattle breeds, there are limited studies orientated towards bovine behavioural features. This study is focused on mapping genomic signatures of selection which may provide insights of differentiation between neutral and selected polymorphisms. Their effects are studied in the Lidia cattle traditionally selected for agonistic behaviour compared with Spanish breeds showing tamed behaviour. Two different approaches, BayeScan and SelEstim, were applied using genotypic 50K SNP BeadChip data. Both procedures detected two genomic regions bearing genes previously related to behavioural traits. The frequencies of the selected allele in these two regions in Lidia breed were opposite to those found in the tamed breeds. In these genomic regions, several putative genes associated with enriched metabolic pathways related to the behavioural development were identified, as neurochondrin gene (NCDN) or glutamate ionotropic receptor kainate type subunit 3 (GRIK3) both located at BTA3 or leucine-rich repeat and Ig domain containing 2 (LINGO2) and phospholipase A2-activating protein (PLAA) at BTA8.
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    Comparison of diversity parameters from SNP, microsatellites and pedigree records in the Lidia cattle breed
    (Livestock Sicence, 2019) Eusebi, Paulina; Cañón Ferreras, Francisco Javier; Dunner Boxberger, Helene Susana; Cortés Gardyn, Óscar; Sevane Fernández, Natalia
    Genetic drift, loss of heterozygosity and decrease in genetic variability are consequences of high rates of inbreeding over generations. High density single nucleotide polymorphisms arrays offered new possibilities to estimate inbreeding coefficients more accurately than those from pedigree records or microsatellites genotypes. In the present study different inbreeding coefficients were estimated and compared from SNP data: (1) runs of homozygosity of different length (>1Mb, > 4Mb, > 8Mb and > 16Mb), (2) inbreeding coefficients based on the observed vs. expected number of homozygous genotypes and (3) standardized observed homozygosity, from pedigree records and from three microsatellite derived diverse metrics. SNP inbreeding coefficients ranging from 0.14 to 0.26 and shown correlations ≥ 0.84 among them. The correlation among SNP and pedigree inbreeding coefficients was moderate ranged from 0.37 to 0.5 and low than the expected correlation. The limited pedigree depth of the Lidia cattle breed as revealed the average number of equivalent complete generations (5.5) probably explain that the higher correlation coefficient with pedigree records was with the runs of homozygosity of high length (>16Mb). Also, the absence of identity disequilibrium on our molecular data could explain the moderate correlation values (0.43–0.54 in absolute values) among microsatellite derived metrics and SNP inbreeding coefficients.