Person:
Roda Navarro, Pedro

Profile Picture
First Name
Pedro
Last Name
Roda Navarro
URI
https://hdl.handle.net/20.500.14352/78990
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Medicina
Department
Inmunología, Oftalmología y ORL
Area
Inmunología
Identifiers
UCM identifierORCIDScopus Author IDWeb of Science ResearcherIDDialnet IDGoogle Scholar ID

Filters

20221
Reset filters

Settings

Author: Carrasco Padilla, Carlos ×

Search Results

Now showing 1 - 2 of 2
  • Thumbnail Image
    Item
    Project number: 238
    Presentación y discusión de trabajos científicos de respuesta inmune a la infección en congresos
    () García de Yébenes Mena, Virginia; Roda Navarro, Pedro; Iborra Martín, Salvador; Fernández Messina, Lola María; Fernandez Arquero, Miguel; Álvarez Corrales, Emigdio; Redondo Urzainqui, Ana; Hernández García, Elena; Aguilar Sopeña, Óscar; Carrasco Padilla, Carlos
    El proyecto ha tenido como objetivo proporcionar a los alumnos del máster de Investigación en Inmunología de la UCM una formación teórica y práctica para la presentación de trabajos científicos en congresos. Se ha desarrollado una reunión científica en la que los alumnos han presentado y discutido trabajos científicos relevantes relacionados con la asignatura “Interacción Patógeno Sistema Inmunitario (607653)” en los formatos de presentación oral y presentación en póster que se utilizan en las reuniones científicas
  • Thumbnail Image
    Item
    Bispecific Antibody Format and the Organization of Immunological Synapses in T Cell-Redirecting Strategies for Cancer Immunotherapy
    (Pharmaceutics, 2022) Carrasco Padilla, Carlos; Hernaiz Esteban, Alicia; Álvarez Vallina, Luis; Aguilar Sopeña, Óscar; Roda Navarro, Pedro
    T cell-redirecting strategies have emerged as effective cancer immunotherapy approaches. Bispecific antibodies (bsAbs) are designed to specifically recruit T cells to the tumor microenvironment and induce the assembly of the immunological synapse (IS) between T cells and cancer cells or antigen-presenting cells. The way that the quality of the IS might predict the effectiveness of T cell-redirecting strategies, including those mediated by bsAbs or by chimeric antigen receptors (CAR)-T cells, is currently under discussion. Here we review the organization of the canonical IS assembled during natural antigenic stimulation through the T cell receptor (TCR) and to what extent different bsAbs induce T cell activation, canonical IS organization, and effector function. Then, we discuss how the biochemical parameters of different formats of bsAbs affect the effectivity of generating an antigen-induced canonical IS. Finally, the quality of the IS assembled by bsAbs and monoclonal antibodies or CAR-T cells are compared, and strategies to improve bsAb-mediated T cell-redirecting strategies are discussed.