Person:
López Torres, Mónica

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First Name
Mónica
Last Name
López Torres
URI
https://hdl.handle.net/20.500.14352/74335
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Ciencias Biológicas
Department
Genética, Fisiología y Microbiología
Area
Fisiología
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Author: Naudí, Alba × Subject: 577.112.3 ×

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    Cysteine dietary supplementation reverses the decrease in mitochondrial ROS production at complex I induced by methionine restriction
    (Journal of Bioenergetics and Biomembranes, 2015) Gómez, A.; Gómez Sánchez, José; López Torres, Mónica; Naudí, Alba; Mota Martorrell, N.; Pamplona, R.; Barja de Quiroga, Gustavo
    It has been described that dietary cysteine reverses many of the beneficial changes induced by methionine restriction in aging rodents. In this investigation male Wistar rats were subjected to diets low in methionine, supplemented with cysteine, or simultaneously low in methionine and supplemented with cysteine. The results obtained in liver showed that cysteine supplementation reverses the decrease in mitochondrial ROS generation induced by methionine restriction at complex I. Methionine restriction also decreased various markers of oxidative and non-oxidative stress on mitochondrial proteins which were not reversed by cysteine. Instead, cysteine supplementation also lowered protein damage in association with decreases in mTOR activation. The results of the present study add the decrease in mitochondrial ROS production to the various beneficial changes induced by methionine restriction that are reversed by cysteine dietary supplementation.