Person:
López Torres, Mónica

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First Name
Mónica
Last Name
López Torres
URI
https://hdl.handle.net/20.500.14352/74335
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Ciencias Biológicas
Department
Genética, Fisiología y Microbiología
Area
Fisiología
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2020 - 20244
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    Project number: 201
    Fomentando biólogos emprendedores desde la asignatura de Proyectos y Estudios en Biología (cuarto curso del Grado de Biología)
    (2022) Morcillo Alonso, Felipe; Beroiz Remírez, Beatriz; Pedro Ormeño, Nuria de; Alfaro Sánchez, David; Jiménez Escobar, María Dolores; López Torres, Mónica; Ortega Moreno, Álvaro Dario; Rello Varona, Santiago; López González-Nieto, Pilar; Urrialde de Andrés, Rafael; Reviriego Eiros, Mario; Pintos López, Beatriz; Roda Ghisleri, Lucía Vera; Sánchez Ballesta, María Teresa; Fernández Messina, Lola María; Trujillo de la Cruz, Marta; Franco López, Daniel; Baratas Díaz, Alfredo
    Este proyecto se elabora con el objetivo principal de fomentar el emprendimiento en los estudiantes de 4º Grado de Biología para que constituyan su empresa, redacten sus proyectos y participen en la Convocatoria de Premios de Emprendimiento Universitario UCM, en la Convocatoria Preincubadora BIO y, potencialmente, en futuras licitaciones públicas. Los miembros del equipo que han participado en el proyecto están o han estado involucrados a lo largo de varios cursos en la docencia de la asignatura de “Proyectos y Estudios en Biología”. El equipo tiene un marcado carácter interdisciplinar ya que está compuesto por profesores que pertenecen a diferentes unidades docentes de todos los departamentos de la Facultad de Ciencias Biológicas, además de dos estudiantes UCM del Grado de Biología y del Máster de Ecología, egresados del curso académico anterior. La metodología seguida para la consecución de los objetivos del proyecto se ha basado en la búsqueda, la obtención, el análisis de documentos necesarios y, finalmente, la elaboración de los materiales didácticos. Los documentos ofrecidos a los estudiantes han sido consultados en torno al 60-70% por ellos en más de 5 ocasiones. La parte que más les ha ayudado, en todos los casos, es la de la estructura de los documentos, y coinciden, en todos los documentos, en la dificultad de comprensión del lenguaje empleado. Aun así, las actividades realizadas durante el desarrollo de este proyecto han permitido que se alcance el objetivo planteado, siendo conscientes de la necesidad de continuar evaluando los resultados del proyecto a largo plazo.
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    Mitochondrial base excision repair positively correlates with longevity in the liver and heart of mammals
    (GeroScience, 2020) Gredilla Diaz, Ricardo; Sánchez-Román Rojas, Inés; Gómez Rodríguez, Alexia; López Torres, Mónica; Barja de Quiroga, Gustavo
    Damage to DNA is especially important for aging. High DNA repair could contribute, in principle, to lower such damage in long-lived species. However, previous studies showed that repair of endogenous damage to nuclear DNA (base excision repair, BER) is negatively or not correlated with mammalian longevity. However, we hypothesize here that mitochondrial, instead of nuclear, BER is higher in long-lived than in short-lived mammals. We have thus measured activities and/or protein levels of various BER enzymes including DNA glycosylases, NTHL1 and NEIL2, and the APE endonuclease both in total and mitochondrial liver and heart fractions from up to eight mammalian species differing by 13-fold in longevity. Our results show, for the first time, a positive correlation between (mitochondrial) BER and mammalian longevity. This suggests that the low steady-state oxidative damage in mitochondrial DNA of long-lived species would be due to both their lower mitochondrial ROS generation and their higher mitochondrial BER. Long-lived mammals do not need to continuously maintain high nuclear BER levels because they release less mitROS to the cytosol. This can be the reason why they tend to show lower nuclear BER values. The higher mitochondrial BER of long-lived mammals contributes to their superior longevity, agrees with the updated version of the mitochondrial free radical theory of aging, and indicates the special relevance of mitochondria and mitROS for aging.
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    Enriching Eggs with Bioactive Compounds through the Inclusion of Grape Pomace in Laying Hens Diet: Effect on Internal and External Egg Quality Parameters
    (Foods, 2024) Herranz Hernández, María Beatriz; Romero, Carlos; Sánchez-Román Rojas, Inés; López Torres, Mónica; Viveros Montoro, Agustín; Arija Martín, Ignacio; Álvarez, María Dolores; De Pascual-Teresa, Sonia; Chamorro Francisco, Susana
    Background: Grapes and their associated by-products (such as grape pomace, GP) stand out for their polyphenol content, which makes them a source of bioactive compounds with antioxidant capacity. The aim of this research was to determine if the inclusion of 50 g/kg of GP in the diet of hens could enrich eggs with antioxidants and to study its effect on internal and external egg quality parameters. Methods: A trial was conducted with two genetic lines of hens, which were fed either a control diet or a diet containing 50 g/kg of GP. Performance, internal and external egg quality, and egg yolk content of vitamins E and A and gallic acid were determined. Results: In eggs laid by hens fed a GP diet, Haugh units and yolk color scores were enhanced, and eggshells became thinner, but without affecting the breaking strength. No dietary effect was observed on the vitamin contents of the yolk. A higher gallic acid content was observed in the yolks of eggs laid by hens fed the GP diet, suggesting that some dietary phenolic compounds could be transferred to the eggs. Hen genetics influenced egg weight, albumen Haugh units, shell thickness, and α- and γ-tocopherol concentration in yolks. Conclusions: Dietary inclusion of GP improved the internal quality of eggs, enriching yolks with a phenolic compound but reducing shell thickness.
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    Project number: PIMCD409/23-24
    Innovando en la enseñanza de la Fisiología Animal: desarrollo de estrategias educativas que impulsan un aprendizaje activo (INNOVAFANI)
    (2024) Sánchez-Román Rojas, Inés; Alonso Gomez, Aitana; Barany Ruiz, André; Chamorro Francisco, Susana; Delgado Saavedra, María Jesús; Estrada Donate, Noa; Fernández Rupérez, Laura; Gómez Boronat, Miguel; González Rodríguez, Tanausú; Herranz Clemente, Tania; Herrera Castillo, Lisbeth Carolina; Iturriaga Barrera, David; Lavesa de Pablo, Carlos; Liter Pérez, Alejandro; López Torres, Mónica; Madera Sánchez, Diego; Minguela Rodríguez, Laura; Montero Sánchez, Laura; Muñoz Sáez, Emma; Rodríguez Benito, Teresa; Saiz Aparicio, Nuria; Sánchez-Camacho Blázquez, Cristina; Soldevilla Navarro, Beatriz; Sánchez-Román Rojas, Inés