Person:
Aranaz Martín, Alicia

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First Name
Alicia
Last Name
Aranaz Martín
URI
https://hdl.handle.net/20.500.14352/80385
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Veterinaria
Department
Sanidad Animal
Area
Sanidad Animal
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2004 - 20092
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    Bovine Tuberculosis (Mycobacterium bovis) in Wildlife in Spain
    (Journal of Clinical Microbiology, 2004) Aranaz Martín, Alicia; Juan Ferré, Lucía De; Montero Serra, Natalia; Sánchez Ramos, Celia; Galka, Margarita; Delso, Consuelo; Álvarez Sánchez, Julio; Romero Martínez, Beatriz; Bezos Garrido, Javier; Vela Alonso, Ana Isabel; Briones Dieste, Víctor; Mateos García, Ana Isabel; Domínguez Rodríguez, Lucas José
    Mycobacterium bovis infection in wildlife and feral species is a potential source of infection for livestock and a threat to protected and endangered species. The aim of this study was to identify Spanish wild animal species infected with M. bovis through bacteriological culture and spacer oligonucleotide typing (spoligotyping) of isolates for epidemiological purposes. This study included samples from red deer (Cervus elaphus), fallow deer (Dama dama), wild boar (Sus scrofa), Iberian lynx (Lynx pardina), hare (Lepus europaeus), and cattle (Bos taurus). They were collected in several geographical areas that were selected for their unique ecological value and/or known relationships between wildlife and livestock. In the areas included in this survey, M. bovis strains with the same spoligotyping pattern were found infecting several wild species and livestock, which indicates an epidemiological link. A locally predominant spoligotype was found in these areas. Better understanding of the transmission and distribution of disease in these populations will permit more precise targeting of control measures.
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    Effect of paratuberculosis on the diagnosis of bovine tuberculosis in a cattle herd with a mixed infection using interferon-gamma detection assay
    (Veterinary Microbiology, 2009) Álvarez Sánchez, Julio; Juan Ferré, Lucía De; Bezos Garrido, Javier; Romero Martínez, Beatriz; Sáez, Jose Luis; Marqués, Sergio; Domínguez, Concepción; Mínguez, Olga; Fernández-Mardomingo, Baudilio; Mateos García, Ana Isabel; Domínguez Rodríguez, Lucas José; Aranaz Martín, Alicia
    Interferon-gamma (IFN-gamma) detection assay is being applied as an ancillary test to tuberculin tests in the diagnosis of bovine tuberculosis to detect the maximum number of infected animals. Among possible factors influencing the performance of tuberculosis-diagnostic tests, paratuberculosis, a widespread disease in Spain and other European countries, has been pointed out as a cause of false positive reactions. Still, its effect on the sensitivity of these tests in cattle has yet to be fully characterized. The impact of paratuberculosis in the apparent sensitivity of IFN-gamma assay was studied in a bullfighting cattle herd with a mixed tuberculosis-paratuberculosis infection, using culture of Mycobacterium bovis and Mycobacterium avium paratuberculosis as the gold standard to determine the infection status of every animal. A total of 218 animals were slaughtered and sampled for bacteriology after blood sampling. IFN-gamma assay showed a lower apparent sensitivity in animals with a mixed infection (50%) compared to all animals suffering tuberculosis (78.3%). This finding indicates that the presence of paratuberculosis in tuberculosis-infected herds could imply a serious impairment in the sensitivity of IFN-gamma detection test.