Person:
Bautista Santa Cruz, José Manuel

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First Name
José Manuel
Last Name
Bautista Santa Cruz
URI
https://hdl.handle.net/20.500.14352/80584
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Veterinaria
Department
Bioquímica y Biología Molecular
Area
Bioquímica y Biología Molecular
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2013 - 20173
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Now showing 1 - 3 of 3
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    First Report of Babesia microti-Caused Babesiosis in Spain
    (Vector-Borne and Zoonotic Diseases, 2016) Arsuaga, M.; Gonzalez, L.M.; Lobo, C.A.; De La Calle, F.; Azcárate, I.G.; Puente, S.; Montero, E.; Bautista Santa Cruz, José Manuel
    Babesiosis is an emerging zoonosis now found in several areas of the world. Using PCR and indirect immunofluorescence assay, we have diagnosed the first case of human babesiosis caused by Babesia microti in Spain. Diagnosis was delayed because of the nonspecific clinical symptoms that occurred in an immunocompetent patient.
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    Iron supplementation in mouse expands cellular innate defences in spleen and defers lethal malaria infection
    (Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2017) Azcárate, I.G.; Sánchez-Jaut, S.; Marín-García, P.; Linares, M.; Pérez-Benavente, S.; García-Sánchez, M.; Uceda, J.; Kamali, A.N.; Morán-Jiménez, M.-J.; Puyet Catalina, Antonio; Díez Martín, Amalia; Bautista Santa Cruz, José Manuel
    The co-endemicity of malnutrition, erythrocytopathies, transmissible diseases and iron-deficiency contribute to the prevalence of chronic anaemia in many populations of the developing world. Although iron dietary supplementation is applied or recommended in at risk populations, its use is controversial due to undesirable outcomes, particularly regarding the response to infections, including highly prevalent malaria. We hypothesized that a boosted oxidative stress due to iron supplementation have a similar impact on malaria to that of hereditary anaemias, enhancing innate response and conditioning tissues to prevent damage during infection. Thus, we have analysed antioxidant and innate responses against lethal Plasmodium yoelii during the first five days of infection in an iron-supplemented mouse. This murine model showed high iron concentration in plasma with upregulated expression of hemoxygenase-1. The sustained homeostasis after this extrinsic iron conditioning, delayed parasitemia growth that, once installed, developed without anaemia. This protection was not conferred by the intrinsic iron overload of hereditary hemochromatosis. Upon iron-supplementation, a large increase of the macrophages/dendritic cells ratio and the antigen presenting cells was observed in the mouse spleen, independently of malaria infection. Complementary, malaria promoted the splenic B and T CD4 cells activation. Our results show that the iron supplementation in mice prepares host tissues for oxidative-stress and induces unspecific cellular immune responses, which could be seen as an advantage to promote early defences against malaria infection.
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    Estandarización de un modelo murino de malaria cerebral en fases clínicas para la evaluación de terapias antimaláricas y de rescate
    (Anales de la Real Academia de Farmacia, 2013) Martínez, Gabriela; Linares Gómez, María; Marín-García, Patricia; Pérez-Benavente, Susana; Puyet Catalina, Antonio; Bautista Santa Cruz, José Manuel; Díez Martín, Amalia
    Entre las enfermedades infecciosas más devastadoras del SNC se incluye la MC, debido a la alta mortalidad y las graves secuelas que ocasiona. Actualmente, no existe tratamiento farmacológico específico, ni de rescate de lesiones neurocognitivas residuales, y su desarrollo está limitado por la inexistencia de modelos experimentales bien definidos. En este trabajo se caracterizó fenotípicamente la infección en un modelo murino de MC evaluando parámetros clínicos que permitieron establecer cuatro estadios de la enfermedad. Este protocolo proporciona el marco experimental adecuado para estudiar terapias coadyuvantes neuroprotectoras que puedan prevenir y/o eliminar las secuelas neurológicas presentes en los individuos que sobreviven.