Person:
Bravo Osuna, Irene

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First Name
Irene
Last Name
Bravo Osuna
URI
https://hdl.handle.net/20.500.14352/77583
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Farmacia
Department
Farmacia Galénica y Tecnología Alimentaria
Area
Farmacia y Tecnología Farmaceútica
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2019 - 201912020 - 20241
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Author: Bravo Osuna, Irene × Subject: 615 ×

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    Chronic glaucoma induced in rats by a single injection of fibronectin-loaded PLGA microspheres: IOP-dependent and IOP-independent eurodegeneration
    (Internationl Journal of Molecular Sciences, 2024) Munuera, Inés; Aragón Navas, Alba; Villacampa, Pilar; González-Cela Casamayor, Miriam Ana; Subías, Manuel; Pablo, Luis E.; García Feijoo, Julián; Herrero Vanrell, María Del Rocío; García Martín, Elena Salobrar; Bravo Osuna, Irene; Rodrigo, María J.
    To evaluate a new animal model of chronic glaucoma induced using a single injection of fibronectin-loaded biodegradable PLGA microspheres (Ms) to test prolonged therapies. 30 rats received a single injection of fibronectin-PLGA-Ms suspension (MsF) in the right eye, 10 received non-loaded PLGA-Ms suspension (Control), and 17 were non-injected (Healthy). Follow-up was performed (24 weeks), evaluating intraocular pressure (IOP), optical coherence tomography (OCT), histology and electroretinography. The right eyes underwent a progressive increase in IOP, but only induced cohorts reached hypertensive values. The three cohorts presented a progressive decrease in ganglion cell layer (GCL) thickness, corroborating physiological age-related loss of ganglion cells. Injected cohorts (MsF > Control) presented greater final GCL thickness. Histological exams explain this paradox: the MsF cohort showed lower ganglion cell counts but higher astrogliosis and immune response. A sequential trend of functional damage was recorded using scotopic electroretinography (MsF > Control > Healthy). It seems to be a function–structure correlation: in significant astrogliosis, early functional damage can be detected by electroretinography, and structural damage can be detected by histological exams but not by OCT. Males presented higher IOP and retinal and GCL thicknesses and lower electroretinography. A minimally invasive chronic glaucoma model was induced by a single injection of biodegradable Ms.
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    Project number: 244
    Diseño de un protocolo de gamificación en el ámbito docente universitario: aplicación en el fomento del proceso de aprendizaje y la adquisición dinámica de competencias en el contexto de la Tecnología Farmacéutica
    (2019) Gil Alegre, María Esther; Martín Erdocia, Izaskun; Molina Martínez, Irene Teresa; Pastoriza Abal, María Pilar; Veiga Ochoa, María Dolores; Herrero Vanrell, María Del Rocío; Bravo Osuna, Irene; Ruiz Caro, Roberto; Arranz Romera, Alicia; Esteban Pérez, Sergio; Andrés Guerrero, Vanesa
    ¿Se puede diseñar un protocolo de gamificación que implique a distintas personas de la comunidad universitaria, que se pueda adaptar a los perfiles de la nueva generación de estudiantes y a los aprendizajes o competencias a adquirir?.