Person:
Vázquez Osorio, María Teresa

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First Name
María Teresa
Last Name
Vázquez Osorio
URI
https://hdl.handle.net/20.500.14352/79638
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Medicina
Department
Anatomía y Embriología
Area
Anatomía y Embriología Humana
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2012 - 20132
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Author: McHanwell, Stephen × Subject: 611 ×

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    Somatotopy of the Neurons Innervating the Cricothyroid, Posterior Cricoarytenoid, and Thyroarytenoid Muscles of the Rat’s Larynx
    (The Anatomical Record, 2013) Hernández-Morato, Ignacio; Pascual-Font, Arán; Ramírez, Carlos; Matarranz-Echeverría, Jorge; McHanwell, Stephen; Sañudo, Jorge R.; Valderrama-Canales, Francisco J.; Vázquez Osorio, María Teresa
    Neurons innervating the intrinsic muscles of the larynx are located within the nucleus ambiguus but the precise distribution of the neurons for each muscle is still a matter for debate. The purpose of this study was to finely determine the position and the number of the neurons innervat- ing the intrinsic laryngeal muscles cricothyroid, posterior cricoarytenoid, and thyroarytenoid in the rat. The study was carried out in a total of 28 Sprague Dawley rats. The B subunit of the cholera toxin was employed as a retrograde tracer to determine the locations, within the nucleus ambiguus, of the neurons of these intrinsic laryngeal muscles following intramuscular injection. The labelled neurons were found ipsilaterally in the nucleus ambiguus grouped in discrete populations with reproducible rostrocaudal and dorsoventral locations among the sample of animals. Neurons innervating the cricothyroid muscle were located the most ros- tral of the three populations, neurons innervating the posterior cricoary- tenoid were found more caudal, though there was a region of rostrocaudal overlap between these two populations. The most caudal were the neu- rons innervating the thyroarytenoid muscle, presenting a variable degree of overlap with the posterior cricoarytenoid muscle. The mean number (6SD) of labelled neurons was found to be 41 6 9 for the cricothyroid, 39 6 10 for the posterior cricoarytenoid and 33 6 12 for the thyroarytenoid.
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    Morphogenesis of the human laryngeal ventricles
    (Head & Neck, 2012) Pascual-Font, Arán; Rivas, Luis; Hernández-Morato, Ignacio; Rodriguez-Niedenführ, Marc; McHanwell, Stephen; Sañudo, José R.; Viejo Tirado, Fermín; Vázquez Osorio, María Teresa
    Background: Two theories explain the origin of human laryngeal ventricles: (1) ventricles derive from the fifth pharyngeal pouches; (2) development independent from the pouches. Methods: In all, there were 21 serially sectioned human embryos from stages 15 to 23, and 11 fetuses of 9 to 18 weeks. Computer-aided 3-dimentional reconstructions were made. Results: The cranial part of the laryngeal sulcus and future vestibule expands from the pharyngeal floor between the third and fourth pharyngeal pouches during stages 15 and 16 (33-37 days). The primordia of the ventricles appeared at stage 18 (44 days) as 2 lateral swellings in the caudal end of the future vestibule, limited by the third pharyngeal pouches. Active epithelial expansion and subsequent canalization during late embryonic and early fetal periods finalizes their development. Conclusions: The laryngeal ventricles do not derive from the pharyngeal pouches but the median region of the pharyngeal floor between the third and fourth pharyngeal pouches and arches at the caudal end of the future vestibule.