Person:
Parrado Quintela, Concepción

Profile Picture
First Name
Concepción
Last Name
Parrado Quintela
URI
https://hdl.handle.net/20.500.14352/81547
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Ciencias Químicas
Department
Química Analítica
Area
Química Analítica
Identifiers
UCM identifierScopus Author IDDialnet ID

Filters

2018 - 201922020 - 20221
Reset filters

Settings

Author: Sánchez Sánchez, Alfredo × End date: 2022 ×

Search Results

Now showing 1 - 3 of 3
  • Thumbnail Image
    Item
    Project number: 73
    Implementación de aplicaciones móviles como herramientas de enseñanza aprendizaje en Química Analítica
    (2018) Villalonga Santana, Reynaldo; Parrado Quintela, Concepción; Sánchez Sánchez, Alfredo; Reviejo García, Ángel Julio; Pérez Quintanilla, Damián; Díez Sánchez, Paula; Jiménez Falcao, Sandra
  • Thumbnail Image
    Item
    Dendrimers as Soft Nanomaterials for Electrochemical Immunosensors
    (Nanomaterials, 2019) Sánchez Sánchez, Alfredo; Villalonga, Anabel; Martínez García, Gonzalo; Parrado Quintela, Concepción; Villalonga Santana, Reynaldo
    Electrochemical immunosensors are antibody-based affinity biosensors with a high impact on clinical, environmental, food, and pharmaceutical analysis. In general, the analytical performance of these devices is critically determined by the materials and reagents used for their construction, signal production and amplification. Dendrimers are monodisperse and highly branched polymers with three-dimensional structures widely employed as “soft” nanomaterials in electrochemical immunosensor technology. This review provides an overview on the state-of-the-art in dendrimer-based electrochemical immunosensors, focusing on those using polyamidoamine and poly (propylene imine) dendrimers. Special emphasis is given to the most original methods recently reported for the construction of immunosensor architectures incorporating dendrimers, as well as to novel sensing approaches based on dendrimer-assisted signal enhancement strategies.
  • Thumbnail Image
    Item
    Supramolecular Enzymatic Labeling for Aptamer Switch-Based Electrochemical Biosensor
    (Biosensors, 2022) Villalonga Chico, Anabel; Parrado Quintela, Concepción; Diaz, Raúl; Sánchez Sánchez, Alfredo; Mayol Hornero, Beatriz; Martínez-Ruíz, Paloma; Vilela García, Diana; Villalonga Santana, Reynaldo
    Here we report a novel labeling strategy for electrochemical aptasensors based on enzymatic marking via supramolecular host–guest interactions. This approach relies on the use of an adamantane-modified target-responsive hairpin DNA aptamer as an affinity bioreceptor, and a neoglycoconjugate of β-cyclodextin (CD) covalently attached to a redox enzyme as a labeling element. As a proof of concept, an amperometric aptasensor for a carcinoembryonic antigen was assembled on screen-printed carbon electrodes modified with electrodeposited fern-like gold nanoparticles/graphene oxide and, by using a horseradish peroxidase-CD neoglycoenzyme as a biocatalytic redox label. This aptasensor was able to detect the biomarker in the concentration range from 10 pg/mL to 1 ng/mL with a high selectivity and a low detection limit of 3.1 pg/mL in human serum samples.