Person: Satta, Valentina
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First Name
Valentina
Last Name
Satta
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Medicina
Department
Bioquímica y Biología Molecular
Area
Identifiers
2 results
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Item Cannabinoid signalling in the immature brain: Encephalopathies and neurodevelopmental disorders(Biochemical Pharmacology, 2018) Sagredo Ezquioga, Onintza; Palazuelos Diego, Javier; Gutierrez-Rodriguez, Ana; Satta, Valentina; Galve Roperh, Ismael; Martínez Orgado, José AntonioThe endocannabinoid system exerts a crucial neuromodulatory role in many brain areas that is essential for proper regulation of neuronal activity. The role of cannabinoid signalling controlling neuronal activity in the adult brain is also evident when considering its contribution to adult brain insults or neurodegenerative diseases. In the context of brain genetic or acquired encephalopathies administration of cannabinoid-based molecules has demonstrated to exert symptomatic relief and hence, they are proposed as new potential therapeutic compounds. This review article summarizes the main evidences indicating the beneficial action of cannabinoid-derived molecules in preclinical models of neonatal hypoxia/ischemic damage. In a second part, we discuss the available evidences of therapeutic actions of cannabidiol in children with refractory epilepsy syndromes. Finally, we discuss the current view of cannabinoid signalling mechanisms active in the immature brain that affect in neural cell fate and can contribute to long-term neural cell plasticity.- Project number: 270
Item Puesta en marcha del curso on line “Envejecimiento y enfermedades neurodegenerativas” en la plataforma Miriadax(2019) Lago Femia, Eva de; Sagredo Ezquioga, Onintza; García García, María De La Concepción; Hernández Galvez, María Luz; Gómez Ruiz, María; Ramos Atance, José Antonio; Fernandez Ruiz, José Javier; Rodríguez Cueto, Carmen; de Castro Vitores, Jacinto; López Blanco, Olga; Esteban Cubero, Amparo; Satta, Valentina; Espejo Porras, Francisco; Santos-García, Irene; García Toscano, Laura; Alonso Gómez, CristinaEste informe detalla los objetivos, actividades y métodos llevados a cabo durante la ejecución de un proyecto de innovación docente que tiene como objetivo implementar un curso online en abierto sobre las enfermedades neurodegenerativas y el envejecimiento.