Person:
Saiz-Pardo Sanz, Melchor

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First Name
Melchor
Last Name
Saiz-Pardo Sanz
URI
https://hdl.handle.net/20.500.14352/78881
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Medicina
Department
Medicina Legal, Psiquiatría y Patología
Area
Anatomía Patológica
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End date: 2019 × Start date: 2019 ×

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    Mesoporous bioactive glass/epsilon-polycaprolactone scaffolds promote bone regeneration in osteoporotic sheep
    (Acta Biomaterialia, 2019) Gómez Cerezo, María Natividad; Casarrubios Molina, Laura; Saiz-Pardo Sanz, Melchor; Ortega, Luis; de Pablo, David; Díaz-Güemes, Idoia; Fernández-Tomé, Blanca; Enciso, Sivlia; Sánchez-Margallo, Francisco Miguel; Portolés Pérez, María Teresa; Arcos Navarrete, Daniel; Vallet Regí, María Dulce Nombre
    Macroporous scaffolds made of a SiO2-CaO-P2O5 mesoporous bioactive glass (MBG) and epolycaprolactone (PCL) have been prepared by robocasting. These scaffolds showed an excellent in vitro biocompatibility in contact with osteoblast like cells (Saos 2) and osteoclasts derived from RAW 264.7 macrophages. In vivo studies were carried out by implantation into cavitary defects drilled in osteoporotic sheep. The scaffolds evidenced excellent bone regeneration properties, promoting new bone formation at both the peripheral and the inner parts of the scaffolds, thick trabeculae, high vascularization and high presence of osteoblasts and osteoclasts. In order to evaluate the effects of the local release of an antiosteoporotic drug, 1% (%wt) of zoledronic acid was incorporated to the scaffolds. The scaffolds loaded with zoledronic acid induced apoptosis in Saos 2 cells, impeded osteoclast differentiation in a time dependent manner and inhibited bone healing, promoting an intense inflammatory response in osteoporotic sheep.