Person: Ramos Alonso, Eva
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First Name
Eva
Last Name
Ramos Alonso
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Veterinaria
Department
Farmacología y Toxicología
Area
Toxicología
Identifiers
8 results
Search Results
Now showing 1 - 8 of 8
Item Toxicology of Blister Agents: Is Melatonin a Potential Therapeutic Option?(Diseases, 2021) Romero Martínez, Manuel Alejandro; Ramos Alonso, Eva; López Muñoz, Francisco; Ríos, Cristóbal de los; Egea, Javier; Gil Martín, Emilio; Pita Pita, Rene; Torrado Durán, Juan José; Serrano López, Dolores Remedios; Juberias, AntonioBlister or vesicant chemical warfare agents (CWAs) have been widely used in different military conflicts, including World War I and the Iran-Iraq War. However, their mechanism of action is not fully understood. Sulfur and nitrogen mustard exert toxic effects not only through the alkylation of thiol-bearing macromolecules, such as DNA and proteins, but also produce free radicals that can develop direct toxic effects in target organs such as the eyes, skin, and respiratory system. The lack of effective treatments against vesicant CWAs-induced injury makes us consider, in this complex scenario, the use and development of melatonin-based therapeutic strategies. This multifunctional indoleamine could facilitate neutralization of the oxidative stress, modulate the inflammatory response, and prevent the DNA damage, as well as the long-term health consequences mediated by vesicant CWAs-induced epigenetic mechanisms. In this context, it would be essential to develop new galenic formulations for the use of orally and/or topically applied melatonin for the prophylaxis against vesicant CWAs, as well as the development of post-exposure treatments in the near future.- Project number: PMICD302/23-24
Item Página web orientada a la evaluación toxicológica “in silico” de nuevas sustancias con interés biológico 2023-24(2024) Ramos Alonso, Eva; Romero Martínez, Manuel Alejandro; De Los Ríos Salgado, Cristóbal; Egea Máiquez, Francisco Javier; García Cantón, Carolina; Pita Pita, Rene; Rodríguez Martín, Abigail; Rodríguez Talavera, María; Suero Martín, Alba; Ramos Alonso, Eva Item Melatonin as Modulator for Sulfur and Nitrogen Mustard-Induced Inflammation, Oxidative Stress and DNA Damage: Molecular Therapeutics(Antioxidants, 2023) Ramos Alonso, Eva; Gil Martín, Emilio; Ríos, Cristóbal de los; Egea, Javier; López Muñoz, Francisco; Pita Pita, Rene; Juberías, Antonio; Torrado Durán, Juan José; Serrano López, Dolores Remedios; Reiter, Russel J.; Romero Martínez, Manuel AlejandroSulfur and nitrogen mustards, bis(2-chloroethyl)sulfide and tertiary bis(2-chloroethyl) amines, respectively, are vesicant warfare agents with alkylating activity. Moreover, oxidative/nitrosative stress, inflammatory response induction, metalloproteinases activation, DNA damage or calcium disruption are some of the toxicological mechanisms of sulfur and nitrogen mustard-induced injury that affects the cell integrity and function. In this review, we not only propose melatonin as a therapeutic option in order to counteract and modulate several pathways involved in physiopathological mechanisms activated after exposure to mustards, but also for the first time, we predict whether metabolites of melatonin, cyclic-3-hydroxymelatonin, N1-acetyl-N2-formyl-5-methoxykynuramine, and N1-acetyl-5-methoxykynuramine could be capable of exerting a scavenger action and neutralize the toxic damage induced by these blister agents. NLRP3 inflammasome is activated in response to a wide variety of infectious stimuli or cellular stressors, however, although the precise mechanisms leading to activation are not known, mustards are postulated as activators. In this regard, melatonin, through its anti-inflammatory action and NLRP3 inflammasome modulation could exert a protective effect in the pathophysiology and management of sulfur and nitrogen mustard-induced injury. The ability of melatonin to attenuate sulfur and nitrogen mustard-induced toxicity and its high safety profile make melatonin a suitable molecule to be a part of medical countermeasures against blister agents poisoning in the near future.- Project number: 165
Item Página web orientada a la evaluación “in silico” de nuevas sustancias con interés biológico IV(2021) Ramos Alonso, Eva; Romero Martínez, Manuel Alejandro; García Cantón, Carolina; Marco Contelles, José Luis; Pita Pita, Rene; Rodríguez Martín, Abigail; Rodríguez Talavera, María - Project number: 150
Item Página web orientada a la evaluación in silico de nuevas sustancias con interés biológico (parte V)(2022) Ramos Alonso, Eva; Romero Martínez, Manuel Alejandro; García Cantón, Carolina; Pita Pita, Rene; Rodríguez Martín, Abigail; Rodríguez Talavera, María; Marco Contelles, José Luis - Project number: 274
Item Página web orientada a la evaluación “in silico” de nuevas sustancias con interés biológico. Parte II(2019) Romero Martínez, Manuel Alejandro; Ramos Alonso, Eva; García Cantón, Carolina; Pita Pita, Rene; Díaz Peralta, Pedro; Marco Contelles, Jose Luis; Rodriguez Martín, Abigail - Project number: 190
Item Página web orientada a la evaluación in silico de nuevas sustancias con interés biológico (parte VI)(2023) Ramos Alonso, Eva; Marco Contelles, José Luis; Pita Pita, Rene; Rodríguez Martín, Abigail; Rodriguez Talavera, María; Egea, Javier; Paramo Muñoz, Ana; Ríos, Cristóbal de los; Romero Martínez, Manuel Alejandro; García Cantón, CarolinaEn la línea de las ediciones anteriores, los resultados obtenidos con el proyecto "INSILITOX" han sido muy positivos. Por esta razón, el equipo se ha propuesto continuar optimizando la página web añadiendo nuevos recursos que apoyen la formación de los estudiantes, tanto de Grado como de Posgrado, en este entorno multilingüe de aprendizaje virtual adaptativo. - Project number: 101
Item Página web orientada a la evaluación “in silico” de nuevas sustancias con interés biológico. Parte III(2020) Ramos Alonso, Eva; Romero Martínez, Manuel Alejandro; Rodríguez Martín, Abigail; Rodríguez Talavera, María; Marco Contelles, José Luis; García Cantón, Carolina; Pita Pita, Rene