Person:
Leza Cerro, Juan Carlos

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First Name
Juan Carlos
Last Name
Leza Cerro
URI
https://hdl.handle.net/20.500.14352/79414
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Medicina
Department
Farmacología y Toxicología
Area
Farmacología
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2013 - 20202
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Author: Carrasco Perera, José Luis × Subject: 612.8 ×

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Now showing 1 - 2 of 2
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    Inflammatory activation and cholinergic anti-inflammatory system in eating disorders
    (Brain, Behavior, and Immunity, 2013) Güemes, Itziar; Rodríguez, Alberto; Mac-Dowell Mata, Karina Soledad; Díaz Marsa, Marina Francisca; Leza Cerro, Juan Carlos; Carrasco Perera, José Luis
    Dysfunctional serotoninergic regulation and hypothalamic-pituitary-adrenal (HPA) axis overreactivity have been consistently reported in research studies with eating disorders (ED). In addition, the links between stress response, serotonin function, HPA axis and inflammatory mechanisms in ED have also been suggested in a number of studies. In our study, inflammatory parameters in white blood cells were investigated in 26 female patients with ED and 25 healthy control subjects matched for sex, age and ethnicity. Patients were free of medication for at least two weeks at the time of the study. Results showed a significant increase in plasma levels of the proinflammatory cytokine IL1β and the protein expression of cyclooxygenase 2 (COX2) in peripheral mononuclear blood cells (PMBCs) in ED patients compared with controls. As well as a significant increase of the oxidative-nitrosative marker TBARS (Thiobarbituric Acid Reactive Substances) in plasma. These findings were associated with increased expression of the alpha7 subunit of the nicotinic receptor (α7nAChR) in PMBC in ED patients independent of plasma cotinine levels. These results suggest that a pro-inflammatory and oxidant phenotype might be present in ED patients. Further research on cellular inflammatory and anti-inflammatory pathways might be oriented to investigate differences between ED subtypes and to search for new potential targets for pharmacological treatment.
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    Decreased oxytocin plasma levels and oxytocin receptor expression in borderline personality disorder
    (Acta Psychiatrica Scandinavica, 2020) Buenache, E.; De la Vega, I.; López‐Villatoro, J. M.; Moreno Moreno, Beatriz; Carrasco Perera, José Luis; Mac-Dowell Mata, Karina Soledad; Díaz Marsa, Marina Francisca; Leza Cerro, Juan Carlos
    Introduction: Borderline personality disorder (BPD) is characterized by intense affective reactions with underlying social and interpersonal cognitive deficits. Oxytocin has largely been associated with both stress regulation and social cognition in psychiatric patients and in non-clinical populations in previous studies. Finally, abnormal oxytocin levels have been preliminary reported in BPD patients. Methods: 53 patients with moderate-severe BPD and 31 healthy control subjects were investigated for plasma levels of oxytocin and protein expression of oxytocin receptor in blood mononuclear cells. Clinical assessments were made for severity, functionality, and comorbidity with axis I and II conditions. Results: Oxytocin plasma levels were significantly lower in BPD patients compared with controls. In addition, protein expression of oxytocin receptor was significantly reduced in the BPD group. A positive correlation was found between plasma oxytocin levels and the activity index score of the Zuckerman-Kuhlman Personality Questionnaire (ZKPQ). Oxytocin receptor protein expression, on the contrary, had a negative correlation with the ZKPQ sociability index score. Conclusions: Results support the evidence of a dysfunction of the oxytocin system in borderline personality disorder, which could be involved in emotional dysregulation and interpersonal disturbances in these patients.