Person:
Leza Cerro, Juan Carlos

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First Name
Juan Carlos
Last Name
Leza Cerro
URI
https://hdl.handle.net/20.500.14352/79414
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Medicina
Department
Farmacología y Toxicología
Area
Farmacología
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20211
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Author: Rodríguez Jiménez, Roberto × Subject: 616.89-02 ×

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    The interplay between functioning problems and symptoms in first episode of psychosis: An approach from network analysis
    (Journal of Psychiatric Research, 2021) Ana Izquierdo; María Cabello; Itziar Leal; Blanca Mellor-Marsá; Miriam Ayora; María-Fe Bravo-Ortiz; Ángela Ibáñez; Karina S. MacDowell; Norberto Malpica; Enrique Baca-García; Natalia E. Fares-Otero; Helena Melero; Pilar López-García; Covadonga M. Díaz-Caneja; Jose Luis Ayuso-Mateos; Manuel Durán-Cutilla; Jessica Merchán-Naranjo; Roberto Mediavilla-Torres; Ainoa Muñoz-Sanjosé; Luis Sanchez-Pastor; Monica Dompablo; Patricia Fernández-Martín; Pablo Puras-Rico; Lucía Albarracin-García; Melero Carrasco, Helena; Rodríguez Jiménez, Roberto; Díaz Marsa, Marina Francisca; Arango López, Celso; García-Albea Martín, Julia Isabel; Leza Cerro, Juan Carlos; Leticia León Quismondo
    The relationship between psychotic symptoms and global measures of functioning has been widely studied. No previous study has assessed so far the interplay between specific clinical symptoms and particular areas of functioning in first-episode psychosis (FEP) using network analysis methods. A total of 191 patients with FEP (age 24.45 ± 6.28 years, 64.9% male) participating in an observational and longitudinal study (AGES-CM) comprised the study sample. Functioning problems were assessed with the WHO Disability Assessment Schedule (WHODAS), whereas the Positive and Negative Syndrome Scale (PANSS) was used to assess symptom severity. Network analysis were conducted with the aim of analysing the patterns of relationships between the different dimensions of functioning and PANSS symptoms and factors at baseline. According to our results, the most important nodes were “conceptual disorganization”, “emotional withdrawal”, “lack of spontaneity and flow of conversation”, “delusions”, “unusual thought content”, “dealing with strangers” and “poor rapport”. Our findings suggest that these symptoms and functioning dimensions should be prioritized in the clinical assessment and management of patients with FEP. These areas may also become targets of future early intervention strategies, so as to improve quality of life in this population.