Person:
González Burgos, Elena María

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First Name
Elena María
Last Name
González Burgos
URI
https://hdl.handle.net/20.500.14352/77699
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Farmacia
Department
Farmacología, Farmacognosia y Botánica
Area
Farmacología
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    Manual de casos clínicos de Farmacología
    (2023) González Burgos, Elena María; Garcimartín Álvarez, Alba; García Aguilar, Ana; Bocanegra De Juana, Aranzazu; García García, Luis; Gómez Oliver, Francisca; Manzano Lista, Francisco Javier; Ureña Vacas, Isabel María; Redondo Castillejo, Rocío
    Este manual de casos clínicos de Farmacología, creado como recurso educativo en abierto (REA) para garantizar una educación inclusiva, equitativa y de calidad, constituye una excelente herramienta didáctica para los procesos de enseñanza y aprendizaje en esta área de conocimiento. En este manual se recopilan un total de 15 casos clínicos agrupados en tres grandes bloques: farmacología del sistema nervioso periférico, farmacología de los mediadores celulares y farmacología de los ejes neuroendocrinos. Estos casos clínicos permiten organizar y relacionar los conocimientos adquiridos sobre farmacología, así como ampliarlos y aplicarlos contribuyendo a la consolidación de un aprendizaje significativo integrado y al desarrollo de competencias deductivas y resolutivas.
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    Guía de Ejercicios de Prácticas de Farmacología General
    (2024) García García, Luis; Gómez Oliver, Francisca; González Burgos, Elena María; Bedoya Del Olmo, Luis Miguel; Garcimartín Álvarez, Alba; Fernández Alfonso, María Soledad; Bocanegra De Juana, Aranzazu; García Aguilar, Ana; Martín-Aragón Álvarez, Sagrario; Bermejo Bescos, María De La Paloma
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    Association between tricyclic antidepressants and health outcomes among older people: A systematic review and meta-analysis
    (Maturitas, 2024) Santandreu, Javier; Caballero, Francisco Félix; Gómez-Serranillos Cuadrado, María Pilar; González Burgos, Elena María
    Tricyclic antidepressants are effective for managing depression and other disorders. However, they can cause adverse reactions due to their anticholinergic properties, with the risk of such events increasing with age. This study identifies and describes clinical studies that evaluate associations between the use of tricyclic antidepressants and adverse health outcomes (falls, fractures, and mortality) among older people. A systematic search of the literature in English, Spanish, and French was conducted using the electronic databases PubMed, ISI Web of Science, PsycINFO, and Cochrane. The systematic review included a total of 18 studies. The meta-analysis examined the 14 studies that investigated the association between the use of tricyclic antidepressants and the risk of falls and fractures (4 of the 18 studies focused on mortality and so were excluded from the meta-analysis). The odds ratio (OR) was 1.40 (95 % CI = 1.27–1.53, p < 0.001). The Cochran Q test was significant (X2 = 79.72, p < 0.001), indicating high heterogeneity (I 2 = 84.9 %). An additional meta-analysis was conducted on studies reporting hazard ratios (HRs), yielding an HR of 1.21 (95 % CI = 0.93–1.58, p = 0.16). Meta-regression analysis indicated that the years of follow-up could have a significant effect on the association studied (p = 0.008). In conclusion, enhancing our understanding of the use of antidepressants and the associated risk of adverse events in older adults will enable the identification of the most appropriate type of antidepressant for each clinical situation.
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    Nutritional Value of Moringa oleifera Lam. Leaf Powder Extracts and Their Neuroprotective Effects via Antioxidative and Mitochondrial Regulation
    (Nutrients, 2021) González Burgos, Elena María; Ureña Vacas, Isabel María; Sánchez Gómez-Serranillos, Marta; Gómez-Serranillos Cuadrado, María Pilar
    Age-related neurodegenerative disorders are an increasing public health problem. Oxidative stress is one of the major causes. Medicinal plant-based functional foods can be effective for these diseases. The aim of this work is to investigate the neuroprotective role of methanol extracts of Moringa oleifera leaf powder on antioxidant/oxidant imbalance and mitochondrial regulation in a H2O2-induced oxidative stress model in human neuroblastoma cells. On nutritional analysis, results showed that moringa contained 28.50% carbohydrates, 25.02% proteins, 10.42% fat, 11.83% dietary fiber, 1.108 mg β-carotene, 326.4 µg/100 g vitamin B1 and 15.2 mg/100 g vitamin C. In-vitro assays revealed that moringa methanol extracts had more phenolic content and higher antioxidant activity than acetone extracts. Moreover, pretreatments with methanol extracts showed a protective effect against H2O2-induced oxidative damage through increasing cell viability and reducing free radicals. Furthermore, the extract decreased lipid peroxidation and enhanced glutathione levels and antioxidant enzyme activity. Finally, moringa also prevented mitochondrial dysfunction by regulating calcium levels and increasing mitochondrial membrane potential. The most active concentration was 25 µg/mL. In summary, the nutritional and functional properties of Moringa oleifera as a neuroprotective agent could be beneficial to protect against oxidative stress and provide necessary nutrients for a healthy diet.